the uses of non-steroidal anti-inflammatory drugs (nsaids) are limited by a variety of side effects. so research on preparing new analgesic agents is important. according to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. the final compounds 10a-10e and 15a-15d were prep...

substituted schiff bases (hydrazones) 5a-j have been prepared from the starting material 2-chloro pyridine-3-carboxylic acid 1 by a sequence of reactions like reaction with 2-amino-6-nitro benzothiazole (ullamann condensation), thionyl chloride, hydrazine hydrate and different aromatic aldehydes. on cyclocondensation of 5a-j with thioglycolic acid in dry 1,4-dioxane furnished desired compounds ...

mother's mental health status during pregnancy has important effects on fetal growth and development. however, there are few studies concerning association of maternal depression and biophysical profile (bpp) of the fetus. we performed this research to know if maternal depression has any association with fetal bpp score. for measuring depression, farsi version of patient health questionnaire-9 ...

the recognition of seasonal patterns in infectious disease occurrence dates back at least as far as the hippocratic era, but the mechanisms underlying these fluctuations remain poorly understood. many classes of mechanistic hypotheses have been proposed to explain seasonality of various directly transmitted diseases, including at least the following; human activity, seasonal variability in huma...

malaysia is affected by moderate environmental disasters but seldom affected by severe disaster. cameron highland mud floods 2013, hulu langat landslide 2011, tsunami 2004 and highland tower 1993 are some of environmental disaster in malaysia. some of these disasters carry heavy price tags as property and lives are damaged beyond full compensation and repair and health effects as well. this pap...

synthesis, characterization, spectral and theoretical calculations of sodium tetrafluoroborate (iii) (stfb) has been studied in this research. sodium tetrafluoroborate (iii) was synthesized by a sonochemical method and characterized by ir, uv/vis, 11b-nmr and mass spectrometer techniques. the nano compound was characterized by scanning electron microscopy (sem), x-ray powder diffraction (xrd) a...

isolated five known iridoids glycosides (scrophuloside a, harpagoside b, 5-hydroxyloganin, 8-o-acetylharpagide and 6-o-methyl,1-glucopyranosyl catalpol ),one phenyl ethanoid glycoside (verbascoside) and a phenyl ethanol amine (2-(4-chlorobenzyl amino) ethanol ) compound from the methanolic extract of aerial parts of scrophularia oxysepala using by high performance liquid chromatography based on...

chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. in the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and wistar rats by using the writhing and formalin-induced paw edema tests respectively. the activities of the compounds were compared with celecoxib as a referenc...

hyssopus of­ficinalis l. is one of the most important medicinal plants. medicinal herbs are contaminated by microorganisms. conventional methods for reducing of microbial loads such as ethylene oxide, propylene oxide and also use of steam are hazardous and instead, non-thermal process such as microwave and gamma radiation are being used widely in order to eliminate the microbial contaminations ...

conclusions the amount and intensity of physical activity during pregnancy is associated with a lower risk of gestational diabetes mellitus. as a result, the pregnant iranian females have to be encouraged to do regular daily physical activity during pregnancy, if there is no specific contraindication to it. results females who had low total physical activity according to the pregnancy physical ...