a 78-year-old woman was referred for coronary angiography with the chief complaint of exertional angina and dyspnea of a very long duration during routine daily physical activities. she had a history of poorly controlled hypertension and dyslipidemia. coronary angiography revealed diffuse three-vessel disease. interestingly, an unusual branch was noted originating from the mid shaft of the left...

A large animal model of chronic myocardial ischemia and heart failure is crucial for the development of novel therapeutic approaches. In this study we developed a novel percutaneous one- and two-vessel model for chronic myocardial ischemia using a stent coated with a polytetrafluoroethylene tube formed in a bottleneck shape. The bottleneck stent was implanted in the proximal left anterior desce...

PURPOSE To evaluate the diagnostic performance of left coronary bifurcation angles and plaque characteristics for prediction of coronary stenosis by dual-source CT. METHODS 106 patients suspected of coronary artery disease undergoing both coronary computed tomography angiography (CCTA) and invasive coronary angiography (CAG) within three months were included. Left coronary bifurcation angles ...

Coronary artery disease (CAD) has been suggested to alter coronary flow reserve (CFR; the ratio between hyperemic and baseline coronary flow velocities) not only in territories supplied by stenotic arteries but also in angiographically normal, remote regions. However, few data exist regarding the left anterior descending (LAD) coronary artery as the normal index artery. The influence of remote ...

Leukocyte adhesion deficiency or LAD is a congenital immunodeficiency disease characterized by recurrent bacterial infections in which the leukocytes from affected children fail to adhere to endothelial cells and migrate to the site of infection due to heterogeneous defects in the leukocyte integrin CD18 subunit. To assess the feasibility of human gene therapy of LAD, we transduced granulocyte ...

OBJECTIVES The purpose of this study was to evaluate which Doppler-derived flow index best predicts new distal left anterior descending coronary artery (LAD) stenosis in patients with left internal mammary artery (LIMA) graft. BACKGROUND The LIMA flow measurement has been proposed to assess graft function, but it may be misleading in case of new distal LAD stenosis and/or competitive flow fro...

Background: Breast-conserving surgery (BCS) followed by radiotherapy (RT) is the standard of care for women with breast cancer. Evidence shows that RT dose to the heart can result in ischemic heart disease. In this study we compared 3 different RT techniques were for heart, left anterior descending coronary artery (LAD) and lung doses in left breast cancer patients after breast-conserving surge...

We adopted a transcriptome-wide microarray analysis approach to determine the extent to which vascular gene expression is altered as a result of juvenile obesity and identify obesity-responsive mRNAs. We examined transcriptional profiles in the left anterior descending coronary artery (LAD), perivascular fat adjacent to the LAD, and descending thoracic aorta between obese (n = 5) and lean (n = ...

Leukocyte adhesion deficiency or LAD is a congenital immunodeficiency disease characterized by recurrent bacterial infections in which the leukocytes from affected children fail to adhere to endothelial cells and migrate to the site of infection due to heterogeneous defects in the leukocyte integrin CD18 subunit. To assess the feasibility of human gene therapy of LAD, we transduced granulocyte ...

Abstract Background Chest pain in aortic stenosis (AS) has been attributed to the loss of coronary flow reserve however; this not directly quantified date. Purpose To determine whether there is a decrease as cause chest or dyspnea patients with severe AS Methods Patients and normal left ventricular ejection fraction (LVEF) underwent coronariography previous valve replacement. In those without o...