The mechanisms leading to weight loss in patients with chronic obstructive pulmonary disease (COPD) are poorly understood but may involve alterations in macronutrient metabolism. Changes in muscle oxidative capacity and lactate production during exercise suggest glucose metabolism may be altered in COPD subjects. The objective of this study was to determine differences in the rates of glucose p...

A recent observational study in a large cohort of critically ill patients confirms the association between hyperlactatemia and mortality. The mechanisms regulating the rates of lactate production and clearance in critical illness remain poorly understood. During exercise, hyperlactatemia clearly results from an imbalance between oxygen delivery and energy requirements. In critically ill patient...

Introduction The mechanisms of persistent hyperlactemia during endotoxic shock are probably multifactorial. Both hypoperfusion-related anaerobic production and adrenergic-driven aerobic generation have been implicated. More recently an early and severe impairment in exogenous lactate clearance has also been described [1]. Theoretically, an excessive adrenergic response could influence all these...

Suggested citation: Ronco R. Blood lactate as prognostic marker in critically ill children: a problem related to production or clearance? J Pediatr (Rio J). 2005;81:271-2. The temporal evolution of blood lactate levels has been widely used as a prognostic marker in critically ill patients, especially in the unstable phase. In the study published by Koliski et al.1 in this issue of Jornal de Ped...

PURPOSE Blood lactate concentration, [BLa], after swimming events might be influenced by demographic features and characteristics of the swim race, whereas active recovery enhances blood lactate removal. Our aims were to (1) examine how sex, age, race distance, and swim stroke influenced [BLa] after competitive swimming events and (2) develop a practical model based on recovery swim distance to...

PURPOSE This study examined the effects of different pressure threshold inspiratory loads on lactate clearance and plasma acid-base balance during recovery from maximal exercise. METHODS Eight moderately trained males (V˙O(2peak) = 4.29 ± 0.46 L·min⁻¹) performed, on different days, four maximal incremental cycling tests (power started at 0 W and increased by 20 W·min⁻¹) of identical duration ...

Dynamic activities such as running, cycling, and swimming have been shown to effectively reduce lactate in the postexercise period. It is unknown whether core stabilization exercises performed following an intense bout would exhibit a similar effect. Therefore, this study was designed to assess the extent of the lactate response with core stabilization exercises following high-intensity anaerob...

The effects of mild stress on nonoxidative glucose metabolism were studied in the brain of the freely moving rat. Extracellular lactate levels in the hippocampus and striatum were monitored at 2.5-min intervals with microdialysis coupled with an enzyme-based flow injection analysis system. Ten minutes of restraint stress led to a 235% increase in extracellular lactate levels in the striatum. A ...

OBJECTIVES There has been renewed interest in lactate as a risk biomarker in sepsis and septic shock. However, the ability of the odds ratio (OR) and change in the area under the receiver operator characteristic curve (AUC-ROC) to assess biomarker added-value has been questioned. DESIGN, SETTING AND PARTICIPANTS A sepsis cohort was identified from the ICU database of an Australian tertiary re...

Positron-emission tomography and functional MRS imaging signals can be analyzed to derive neurophysiological values of cerebral blood flow or volume and cerebral metabolic consumption rates of glucose (CMR(Glc)) or oxygen (CMR(O(2))). Under basal physiological conditions in the adult mammalian brain, glucose oxidation is nearly complete so that the oxygen-to-glucose index (OGI), given by the ra...