نتایج جستجو برای: lactamase oxa

تعداد نتایج: 15289  

Journal: :Egyptian Journal of Bronchology 2021

Abstract Background Routine administration of antibacterials in patients with Covid-19 has been a subject debate, no solid data about the true prevalence respiratory coinfections different geographic areas. The aim current study was to identify admitted hospital and its genetic resistance pattern using multiplex polymerase chain reaction (PCR). Results included 40 patients, 32 males (80%) 8 (20...

2015
Hiromichi Saino Tomohiro Sugiyabu Go Ueno Masaki Yamamoto Yoshikazu Ishii Masashi Miyano Hendrik W. van Veen

OXA-58 is a class D β-lactamase from the multi-drug resistant Acinetobacter baumannii. We determined the crystal structure of OXA-58 in a novel crystal, and revealed the structure of the substrate-binding cleft in a closed state, distinct from a previously reported OXA-58 crystal structure with the binding cleft in an open state. In the closed state, the movement of three loops (α3-α4, β6-β7, a...

Objective(s):Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. Materials and Methods: For this study, 108 non-duplic...

Journal: :Nature structural biology 2000
M Paetzel F Danel L de Castro S C Mosimann M G Page N C Strynadka

We report the crystal structure of a class D beta-lactamase, the broad spectrum enzyme OXA-10 from Pseudomonas aeruginosa at 2.0 A resolution. There are significant differences between the overall fold observed in this structure and those of the evolutionarily related class A and class C beta-lactamases. Furthermore, the structure suggests the unique, cation mediated formation of a homodimer. K...

Journal: :Antimicrobial agents and chemotherapy 2011
Charline S Antonio Patrícia R Neves Micheli Medeiros Elsa M Mamizuka Maria R Elmor de Araújo Nilton Lincopan

A recent article by Higgins et al. reported the identification of a novel carbapenem-hydrolyzing class D -lactamase (CHDL), defined as OXA-143, in a carbapenem-resistant Acinetobacter baumannii strain isolated in Brazil in 2004 (5). This enzyme, which has 88% identity with OXA-40, is the first representative of a novel subgroup of CHDLs whose prevalence remains to be determined (5). In an attem...

Journal: :The Journal of antimicrobial chemotherapy 2005
Claire Héritier Anne Dubouix Laurent Poirel Nicole Marty Patrice Nordmann

OBJECTIVE The aim of this study was to analyse the spread of the bla(OXA-58) gene as a source of carbapenem resistance in Acinetobacter baumannii in the burns unit of a university hospital in Toulouse in 2003-2004. METHODS Six carbapenem-resistant A. baumannii isolates from six patients, and a carbapenem-resistant environmental A. baumannii isolate were collected in the burns unit of the Rang...

Journal: :Journal of clinical microbiology 2012
Diana Doyle Gisele Peirano Christine Lascols Tracie Lloyd Deirdre L Church Johann D D Pitout

A study was designed to evaluate the modified Hodge test (MHT), Mastdiscs ID inhibitor combination disks (MDI), Rosco Diagnostica Neo-Sensitabs (RDS), metallo-β-lactamase (MBL) Etest, and in-house multiplex PCR for the detection of well-characterized carbapenemase-producing Enterobacteriaceae. One hundred forty-two nonrepeat clinical isolates of carbapenemase-producing Enterobacteriaceae (inclu...

Journal: :Frontiers in Microbiology 2023

The modified carbapenem inactivation method (mCIM) recommended by the Clinical and Laboratory Standards Institute is not applicable for detecting carbapenemases in Acinetobacter baumannii . Four currently reported phenotypic detection methods, namely, Hodge test, mCIM, adjusted simplified (sCIM), did perform well our 90 clinical A. isolates. Thus, minimal inhibitory concentrations (MICs) of car...

Journal: :Antimicrobial agents and chemotherapy 2002
Siaw Eng Ho Geetha Subramaniam Selvi Palasubramaniam Parasakthi Navaratnam

We have isolated and identified a carbapenem-resistant Pseudomonas aeruginosa strain from Malaysia that produces an IMP-7 metallo-beta-lactamase. This isolate showed high-level resistance to meropenem and imipenem, the MICs of which were 256 and 128 micro g/ml, respectively. Isoelectric focusing analyses revealed pI values of >9.0, 8.2, and 7.8, which indicated the possible presence of IMP and ...

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