As part of our ongoing antikinetoplastid structure–activity relationship study focused on positions 2 and 8 the 3-nitroimidazo[1,2-a]pyridine scaffold, we were able to introduce a phenylthioether moiety at both position in one step. Using previously reported synthetic route developed laboratory, obtained 6-chloro-3-nitro-8-(phenylthio)-2-[(phenylthio)methyl]imidazo[1,2-a]pyridine 74% yield. The...

In the title compound, [Ti2(C16H14N2O2)2O2]·2CHCl3, the Ti(IV) atom in the centrosymmetric complex has a distorted octa-hedral N2O4 coordination environment and is linked via two μ2-oxido bridges into a dinuclear centrosymmetric com-plex, with a Ti⋯Ti separation of 2.7794 (8) Å. In the salen (N,N'-ethyl-enebis(salicyl-imine)) ligand, the two salicyl-imine units make a dihedral angle of 45.31 (5...

Books 2005–2009 [website]. Northampton, United Kingdom:Motor Neurone Disease Association. Available: http://www.mndassociation.org/research/for_researchers/ international_symposium/previous.html [accessed 3 Feb 2012]. 46. Rao SD, et al. BMAA selectively injures motor neurons via AMPA/ kainate receptor activation. Exp Neurol 201(1):244–252 (2006); http://dx.doi.org/10.1016/j.expneurol.2006.04.01...

New complexes and adducts of xanthate the general formula [M(cyclopentyl xant.)2] xant.)2.nL] Where M= Mn(ΙΙ) Fe(ΙΙ), Co(ΙΙ), Ni(ΙΙ), Cu(ΙΙ) Zn(ΙΙ), (cyclopentyl xant.)2=[Cyclopentyl ligand], n=2 L= Pyridine, 3-acetyl pyridine & Quinoline n=1, ethylenediamine, (1,10)-phenanthroline, prepared has been evaluated based on their magnetic, electrical, physical characteristics. And spectral metho...

2,2'-disubstitutedamino-4-4'-bis-pyrimidines (3a-m) have been prepared by linking 2,4-dichloro-6-methyl-5-nitropyrimidine (1) with several diamines and subsequent reaction with suitable amines. some of these compounds (3c and 3j) which were reduced catalitically, on treatment with nitrous acid, urea in pyridine, and boiling thionyl chloride gave the corresponding bistriazolopyrimidin ...

The isomerism of zinc complex [Zn(L)2]2+ with tridentate ligand L having acetamide and pyridine groups on each side the central amino- nitrogen atom has been investigated by DFT calculations, liquid state NMR single-crystal X-ray diffraction. was used for obtaining ensembles low-energy conformers calculation parameters all conformers. For generated [Zn(L)2]2+, Mean Absolute Error [MAE(conf)] te...

Room temperature iodocyclisation of homoallylamines stereoselectively delivers functionalised 2-(iodomethyl)azetidine derivatives in high yield. Increasing reaction temperature from 20 °C to 50 °C switches the reaction outcome to realise the stereoselective formation of functionalised 3-iodopyrrolidine derivatives. It was shown that these pyrrolidines are formed via thermal isomerisation of the...

Metal hydrazine, pyridine–2-carboxylate hydrates, pyridine–3-carboxylate hydrates, [ML(N2H4)0.5.H2O] where L = pyridine–2-carboxylic acid, pyridine–3-carboxylic acid and M = Co, Ni, Mn and Zn have been prepared and characterized by analytical, IR, UV-Vis and XRD Studies. Thermal decomposition of the compounds is studied from room temperature to 1200C by TG-DTA analysis. The compounds were found...