نتایج جستجو برای: kor river

تعداد نتایج: 84187  

Journal: :Journal of neurophysiology 2005
Huibert D Mansvelder

In opioid signaling in the brain and -opioid receptors (MOR and KOR) are like the yin and yang principles in Chinese philosophy, they always act as an opposing pair. The antagonistic interactions between MOR and KOR are widespread in the CNS. In few receptor families, two closely related members with such overlapping expression in the brain produce such opposite behavioral effects. In humans, M...

Journal: :Journal of natural products 2013
Jane V Aldrich Sanjeewa N Senadheera Nicolette C Ross Michelle L Ganno Shainnel O Eans Jay P McLaughlin

The macrocyclic tetrapeptide natural product CJ-15,208 (cyclo[Phe-d-Pro-Phe-Trp]) exhibited both dose-dependent antinociception and kappa opioid receptor (KOR) antagonist activity after oral administration. CJ-15,208 antagonized a centrally administered KOR selective agonist, providing strong evidence it crosses the blood-brain barrier to reach KOR in the CNS. Orally administered CJ-15,208 also...

This study provides new data on chromosomal characteristics and DNA barcoding of three endemic loaches of Iran: spiny southern loach Cobitis linea (Heckel, 1847), Persian stream loach Oxynoemacheilus persa (Heckel, 1848) and Tongiorgi stream loach Oxynoemacheilus tongiorgii (Nalbant & Bianco, 1998). The chromosomes of these fishes were investigated by examining metaphase chromosome spreads obta...

Journal: :The Journal of pharmacology and experimental therapeutics 2004
Genya Gekker Shuxian Hu Mark P Wentland Jean M Bidlack James R Lokensgard Phillip K Peterson

Cocaine abuse has been implicated as a cofactor in human immunodeficiency virus (HIV)-1-associated dementia (HAD). In this study, we tested the hypothesis that exposure of microglial cells, the resident macrophages of the brain, to cocaine would potentiate HIV-1 expression. Because kappa-opioid receptor (KOR) agonists have been shown to suppress neurochemical and neurobehavioral responses to co...

Journal: :Pro Futuro 2018

2003
N.Sravanthi S.Renuka K. Rama krishna

The purpose of the study was to compare the binding energy of pharmacophores of different classes targeting to kappa opioid receptor (KOR) with ketazocine and pentazocine which are having good activity on the KOR. The 3D structure of KOR receptor was built by Homology modeling; pharmacophores were characterized by using Ligand scout. Docking studies for the KOR agonists were performed in Autodo...

2013
Kohei Yamamizu Sadayoshi Furuta Yusuke Hamada Akira Yamashita Naoko Kuzumaki Michiko Narita Kento Doi Shiori Katayama Hiroshi Nagase Jun K. Yamashita Minoru Narita

Opioids are effective analgesics for the management of moderate to severe cancer pain. Here we show that κ opioid receptor (KOR) agonists act as anti-angiogenic factors in tumors. Treatment with KOR agonists, U50,488H and TRK820, significantly inhibited human umbilical vein endothelial cell (HUVEC) migration and tube formation by suppressing VEGFR2 expression. In contrast, treatment with a μ op...

2015
Elena H. Chartoff Maria Mavrikaki

Behavioral, biological, and social sequelae that lead to drug addiction differ between men and women. Our efforts to understand addiction on a mechanistic level must include studies in both males and females. Stress, anxiety, and depression are tightly linked to addiction, and whether they precede or result from compulsive drug use depends on many factors, including biological sex. The neuropep...

Journal: :Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2008
R Capasso F Borrelli J Zjawiony L Kutrzeba G Aviello G Sarnelli F Capasso A A Izzo

The hallucinogenic plant Salvia divinorum has been used for medical treatments of gastrointestinal disorders. Here, we evaluated the effect of a standardized extract from the leaves of Salvia divinorum (SDE) and of its active ingredient salvinorin A on motility in vivo, both in physiological states and during croton oil-induced intestinal inflammation. SDE (1-100 mg kg(-1)) significantly inhibi...

2016
Jamie H. Rose Anushree N. Karkhanis Björn Steiniger-Brach Sara R. Jones

The development of pharmacotherapeutics that reduce relapse to alcohol drinking in patients with alcohol dependence is of considerable research interest. Preclinical data support a role for nucleus accumbens (NAc) κ opioid receptors (KOR) in chronic intermittent ethanol (CIE) exposure-induced increases in ethanol intake. Nalmefene, a high-affinity KOR partial agonist, reduces drinking in at-ris...

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