Rhp14 of Schizosaccharomyces pombe is homologous to human XPA and Saccharomyces cerevisiae Rad14, which act in nucleotide excision repair of DNA damages induced by ultraviolet light and chemical agents. Cells with disrupted rhp14 were highly sensitive to ultraviolet light, and epistasis analysis with swi10 (nucleotide excision repair) and rad2 (Uve1-dependent ultraviolet light damage repair pat...

Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira. The whole-genome sequence of L. interrogans serovar Copenhageni together with bioinformatics tools represent a great opportunity to search for novel antigen candidates that could be used as subunit vaccine against leptospirosis. We focused on six genes encoding for conserved hypothetical proteins predicted to be exported to ...

Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic applications. Recent data indicate that PTD-mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to approximately 5. Nitrilotriacetic acid (NTA)-coordinated metals avidly bind hexahistidine-tagg...

In the Middle Ages superbly crafted and precious artworks were used to glorify God as well as to attract more money through gifts and donations to institutions like monasteries and cathedrals. Wealthy individuals like kings, lords and bishops also amassed art objects in order to display their power. But it is only with Jean, Duc de Berry (1340±1416) that we can see the frenzy of accumulation, a...

Dedicated To my wife, Dohee Kwon v Acknowledgement First of all, I would like to express my deep gratitude to my advisor, Dr. Arumugam Manthiram, for having guided me to finish my research successfully and provided me precious support and constant encouragement. Without his support, it would have taken much longer to finish my work.

This paper introduces the clinical experiences on acupuncture and moxibustion of Zhang Zhongjing, who was regarded as “medical Saint” of Traditional Chinese Medicine. He gave indications for acupuncture and moxibustion, developed robbing fire or inversing fire acupuncture principles to treat febrile diseases. His theories on acupuncture and moxibustion are precious and could be reference in cli...

History of Pharmacy Museum at the Faculty of Pharmacy University of Belgrade was founded in Belgrade in 1952, thanks to many pharmacists and historians, but especially to Mr Andrija Mirković (Mpharm). His precious private collection of antiquities, which he donated to the Faculty of Pharmacy in Belgrade, subsequently a basic one for the Museum foundation, included apothecary vessels, apparatuse...