نتایج جستجو برای: knock
تعداد نتایج: 15938 فیلتر نتایج به سال:
The molecular mechanism underlying renal hypertrophy and progressive nephron damage remains poorly understood. Here we generated congenic ribosomal protein S6 (rpS6) knock-in mice expressing nonphosphorylatable rpS6 and found that uninephrectomy-induced renal hypertrophy was significantly blunted in these knock-in mice. Uninephrectomy-induced increases in cyclin D1 and decreases in cyclin E in ...
Vesicular (v)- and target (t)-SNARE proteins assemble in SNARE complex to mediate membrane fusion. Tetanus neurotoxin-insensitive vesicular-associated membrane protein (TI-VAMP/VAMP7), a vesicular SNARE expressed in several cell types including neurons, was previously shown to play a major role in exocytosis involved in neurite growth in cultured neurons. Here we generated a complete constituti...
This paper studies the effect of nitric oxide (NO) on the onset of knock in a cooperative fuel research (CFR) engine. The experiments are conducted at both the standard knock intensity (SKI) condition for research octane number (RON) tests, as well as at a richer operating condition of a similar knock intensity but a higher compression ratio. Iso-octane is the fuel. The experiments show clearly...
Cytochrome P450 4x1 (Cyp4x1) is expressed at very high levels in the brain but the function of this protein is unknown. It has been hypothesised to regulate metabolism of fatty acids and to affect the activity of endocannabinoid signalling systems, which are known to influence appetite and energy metabolism. The objective of the present investigation was to determine the impact of Cyp4x1 on bod...
Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or prenatal exposure to the monoamine uptake inhibitor cocaine alters behavior in humans and rodents, but the mechanisms are unclear. In MAOA knock-out mice, inhibiting serotonin synthesis during development can prevent abnormal segregation of axons in the retinogeniculate and somatosensory thalamocortical systems. To inv...
Nowadays, an area-based approach seems to be common for urban policies in Western Europe. Policies are directed towards spatially defined areas in order to be more efficient in solving problems in cities. Yet, besides solving problems in the targeted area, an area-based approach has an in-built danger: it might lead to a displacement of problems. This so-called spatial knock-on effect is an eff...
This paper presents an experimental investigation into the detection of excessive diesel knock using acoustic emission (AE) signals. Three different dual-fuel diesel engine operating regimes were induced into a compression-ignition (diesel) engine operating on both straight diesel fuel and two different mixtures of fumigated ethanol and diesel. The experimentally induced engine operating regime...
Experiments to identify the knock trends of lean gasoline-air mixtures, and such mixtures enhanced with hydrogen (H2) and carbon monoxide (CO), were performed on a single-cylinder research engine with boosting capability. The experimental method used to investigate knock trends consisted of determining the octane number (ON) of the primary reference fuel (mixture of isooctane and n-heptane) sup...
Aspergillus oryzae is an industrially relevant organism for the secretory production of heterologous enzymes, especially amylases. The activities potential amylases, however, cannot be quantified directly from supernatant due to high background activity native α-amylase. This caused by gene products amyA, amyB, and amyC. In this study, in vitro CRISPR/Cas9 system was established A. delete these...
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