Brown adipose tissue (BAT) plays an important role in mammalian thermoregulation. The component of BAT mitochondria that permits this function is the inner membrane carrier protein uncoupling protein 1 (UCP1). To the best of our knowledge, no studies have directly quantified UCP1 function in human BAT. Further, whether human and rodent BAT have comparable thermogenic function remains unknown. W...

Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. To control these diseases, research in rodent models that closely mimic th...

Cardiac remodeling and failure are regulated by a myriad of cardiac protein phosphorylations. In the present study, cardiac phosphoprotein patterns were examined in rodent and human hearts Left ventricular tissue samples were obtained from human systolic failing (n = 5) and control (n = 5) hearts and from two rat models of hypertensive heart failure, i.e., spontaneously hypertensive heart failu...

Joven de 19 años que realiza intento suicido en febrero 2019, ingiriendo 04 bolsas raticida “Klerat”. Llevado a Emergencia la ciudad Tarapoto (Región San Martín); le realizan lavado gástrico; recibe Fitomenadiona 2 dosis y lo envían su casa. A los 11 días post- intoxicación presenta dolores osteomusculares, orina color rojizo, se añade sangrado por las encías, epistaxis, hematomas, aumenta ging...

BACKGROUND Integrated vector management strategies depend on local eco-bio-social conditions, community participation, political will and inter-sectorial partnership. Previously identified risk factors for persistent Triatoma dimidiata infestation include the presence of rodents and chickens, tiled roofs, dirt floors, partial wall plastering and dog density. METHODS A community-based interven...

The most serious known rodent pests in agricultural irrigated land are: Rattus rattus, Arvicanthis niloticus and Acomys sp. Occasionally there are rodent outbreaks in agricultural plantations. The changing agro-ecosystem in the present and future agricultural plantations is expected to affect the status of the following potential rodent pest species: Spalax ehrenbergi aegyptiacus, Nesokia indic...

BACKGROUND Widespread but particularly incident in the tropics, leptospirosis is transmitted to humans directly or indirectly by virtually any Mammal species. However, rodents are recognized as the most important reservoir. In endemic regions, seasonal outbreaks are observed during hot rainy periods. In such regions, hot spots can be evidenced, where leptospirosis is "hyper-endemic", its incide...

polyethylenimine (pei) has been proposed as a non-viral vector, and has been successfully used to transfer reporter genes into the central nervous system (cns), kidneys, and lungs of adult mice. neuropeptide y (npy) is a peptide expressed in the hypothalamus and is important in the regulation of body weight. using pei combined with stereotactic microinjection, we have successfully transferred c...

Rodents threaten agricultural industries and food security on a global scale. Rodent management practices routinely involve the use of chemical products, mainly anticoagulant rodenticides (ARs). An understanding farmer rodent control behaviors is crucial in order to implement changes more environmentally friendly practices. In this study, we surveyed farmers an area northwestern Taiwan their kn...