BACKGROUND Glucose-6-phosphate-dehydrogenase-deficiency (G6PDd) is a major risk factor for primaquine-induced haemolysis. There is a need for improved point-of-care and laboratory-based G6PD diagnostics to unsure safe use of primaquine. METHODS G6PD activities of participants in a cross-sectional survey in Bangladesh were assessed using two novel quantitative assays, the modified WST-8 test a...

Sera from patients being treated with phenytoin were analyzed for the drug by spectrophotometry, gas chromatography, radioimmunoassay, enzyme immunoassay, and liquid chromatography. The essay values obtained were intercompared statistically. Enzyme immunoassay and liquid chromatography appear to be attractive alternatives to the more traditional methods of spectrophotometry and gas chromatograp...

OBJECTIVES Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins. Recently, diverse OXA-48-like β-lactamases have been identified worldwide (OXA-162, OXA-181, OXA-163, OXA-204 and OXA-232). They differ by few...

Various aspects of application of derivative spectrophotometry in chemical analysis and in investigations of equilibria and kinetics of reactions are scrutinized. The presented paper provides useful information about state-of-the-art and possibilities offered by derivative spectrophotometry in pharmaceutical, clinical or environmental fields of analysis.

Objective(s): In this work, electrospun nanofibers were explored as drug delivery vehicles using tetracycline as a model drug.  Nanocomposite fibers including chitosan (CS)/poly (ethylene oxide) (PEO) and antibiotic were successfully prepared using electrospinning. CS blended with PEO considering a weight ratio of (90/10), and then, nanofibrous samples were successfully e...

Ultraviolet spectrophotometry has been successfully used for the qualitative as well quantitative determination of various phytoconstituents. For phytoconstituents in extract by ultraviolet spectrophotometry, absorbance at specific wavelength is measured. As a mixture number constituents, different constituents same along with compound interest can occur giving wrong interpretation observed dat...

tidepressants, a group of drugs widely used for treating depressive diseases. Its chemical structure is shown in Fig. 1. Most existing methods for the determination of nortriptyline in bulk, pharmaceutical formulations and biological samples have been reviewed. Among other methods described for the assay of this drug are direct UV-spectrophotometry, derivatives spectrophotometry, fluorimetry an...