In this paper we introduce MULTIVOC, a real-world text-to-speech product geared to the French language. Starting from a ordinary French text, MULTIVOC generates in real-time a high quality speech using a synthesis-by-diphone method. The processing is divided into 3 main transformations (phonetization, automatic prosody and rhythm marking, and generation of LPC frames). This paper provides a ful...

Background: DISCOVER 1&2 (PsA) and VOYAGE (PsO) are Phase 3 trials of guselkumab (GUS). Objectives: Compare safety results through up to 1yr GUS in PsA PsO pts. Methods: In DISCOVER, 1120 pts with active despite standard therapy were treated. Most biologic-naïve; ~30% 1 had previous exposure 1-2 TNFi. Concomitant MTX (57%), oral corticosteroids (17%), NSAIDs (64%) permitted. Pts randomized ...

We analyze the two cut generation scheme in the analytic center cutting plane method. We propose an optimal updating direction when the two cuts are central. The direction is optimal in the sense that it maximizes the product of the new slacks within the trust region de ned by Dikin's ellipsoid. We prove convergence in O (n2 "2 ) calls to the oracle and that the recovery of a new analytic cente...

OF DOCTORAL DISSERTATION HELSINKI UNIVERSITY OF TECHNOLOGY P.O. BOX 1000, FI-02015 TKK http://www.tkk.fi Author Miia Helanto Name of the dissertation Metabolic engineering of lactic acid bacteria for production of mannitol, L-ribulose and L-ribose Manuscript submitted 12.9.2008 Manuscript revised 9.3.2009 Date of the defence 24.4.2009 Monograph Article dissertation (summary + original articles)...

When using the Born–Oppenheimer approximation for molecular systems, one encounters a quantum mechanical Hamiltonian for the electrons that depends on several parameters that describe the positions of the nuclei. As these parameters are varied, the spectrum of the electron Hamiltonian may vary. In particular, discrete eigenvalues may approach very close to one another at “avoided crossings” of ...

We study a nonlinear ltering problem in which the signal to be estimated is conditioned by the Wiener process in the observation equation. The main results establish pathwise uniqueness for the unnormalized lter equation and uniqueness in law for the normalized and unnormalized lter equations. 1 Introduction An early work on uniqueness for the stochastic di erential equations of nonlinear lteri...

The two-stage Kalman estimator was originally proposed to reduce the computational complexity of the augmented state Kalman filter. Recently, it was also applied to the tracking of maneuvering targets by treating the target acceleration as a bias term. Except in certain restrictive conditions, the conventional two-stage estimators are suboptimal in the sense that they are not equivalent to the ...

Key pathological, including oncogenic, signaling pathways regulate the canonical functions of metabolic enzymes that serve cellular needs. Importantly, these also confer a large number to have noncanonical or nonmetabolic are referred as “moonlighting” functions. In this review, we highlight how aberrantly regulated with such activities play critical roles in governing wide spectrum instrumenta...

In this paper, we will compare di ering nonlinear H1 analysis techniques for linear systems with saturation nonlinearities, as applied to low order examples. The examples e ectively show the inter-relationship of stability and the behaviour of the induced norm and incremental gain, and the necessity of using bounded input sets. Finally, the state feedback synthesis problem receives preliminary ...