We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Six compounds displayed NF-κB inhibition, four resulted Tat an...

Objective(s) 7-prenyloxycoumarins including 7-isopentenyloxycoumarin, auraptene and umbelliprenin, and herniarin have been widely recognized as bioactive coumarins. This paper presents the ways to synthesis these compounds. Materials and Methods 7-prenyloxycoumarins were synthesized by reaction between 7-hydroxycoumarin (' M) and relevant prenyl bromides (1.5 M) in acetone at room temperatur...

We describe fluorescence labeling of newly synthesized proteins in Escherichia coli cells by means of Cu(I)-catalyzed cycloaddition between alkynyl amino acid side chains and the fluorogenic dye 3-azido-7-hydroxycoumarin. The method involves co-translational labeling of proteins by the non-natural amino acids homopropargylglycine (Hpg) or ethynylphenylalanine (Eth) followed by treatment with th...

Photochemical release (uncaging) of bioactive messengers with three-dimensional spatial resolution in light-scattering media would be greatly facilitated if the photolysis could be powered by pairs of IR photons rather than the customary single UV photons. The quadratic dependence on light intensity would confine the photolysis to the focus point of the laser, and the longer wavelengths would b...

The status of hepatic function can be altered by diverse influences. Multiple functional processes are measurably affected by several extrinsic toxic agents (typhoid toxin, chloroform, yellow phosphorus) as well as by a large number of pathological disorders. After exposure to toxins, in obstructive jaundice, in cirrhotic processes, in intrahepatic tumors and the like, either anatomical disrupt...

In this work, we attempted to synthesize thallium (III) oxide nano structures by direct thermal decomposition using thallium I phenylsuccinic acid coordination polymer [Tl(PsucH)]n as a precursor. Also, Tl2O3 nanoparticles have been characterized by scanning electron microscopy (SEM), X-Ray powder diffraction (XRD) and IR spectroscopy and then we report a simple and efficient method for the syn...

Solanum nigrum L. has been traditionally used as traditional Chinese medicine and food all over the world. Phytochemical investigations of immature fruits S. have carried out five coumarins (1-5) phenolic compounds (6-11) were obtained. Their structures elucidated on basis spectroscopic chemical methods, including IR, MS, 1H 13C-NMR. They identifies 6,7-dimethoxycoumarin (1), 6-methoxy-7-hydrox...

Coumarin (1,2-benzopyrone) is a natural compound that has been used as a fragrance in the food and perfume industry and could have therapeutic usefulness in the treatment of lymphedema and different types of cancer. Several previous pharmacokinetic studies of coumarin have been performed in humans, which revealed extensive first-pass metabolism of the compound. 7-Hydroxycoumarin (7-HC) and its ...