CS: carcinosarcoma IHC: immunohistochemistry PCCS: primary cutaneous carcinosarcoma SCC: squamous cell carcinoma SCM: spindle cell melanoma SMA: smooth muscle actin SpSCC: spindle cell squamous cell carcinoma INTRODUCTION Malignancy can develop after exposure to ionizing radiation. Basal cell carcinoma, squamous cell carcinoma (SCC), and sarcoma associated with ionizing radiation have been repo...

It is well established that cells are more sensitive to ionizing radiation during the G2/M phase of the cell cycle when their chromatin is highly compacted. However, highly compacted chromatin is less susceptible to DNA Double Strand Breaks (DSBs) than relaxed chromatin. Therefore, it is now becoming apparent that it is the cell capacity to repair its damaged DNA and refold its chromatin into i...

The standard treatment of many tumor entities comprises fractionated radiation therapy which applies ionizing radiation to the tumor-bearing target volume. Ionizing radiation causes double-strand breaks in the DNA backbone that result in cell death if the number of DNA double-strand breaks exceeds the DNA repair capacity of the tumor cell. Ionizing radiation reportedly does not only act on the ...

The radiation spectrum includes forms of radiation that carry various energy levels. Radiation forms, such as x-radiation, which carry sufficient energy to overcome binding energies of electrons and to eject them from their atomic orbits, can cause the formation of ions in the matter through which they travel, and are termed ionizing radiation. Ionizing radiation may also dissociate molecular b...

Radiotherapy has been used to treat cancer for >100 years and is required by numerous patients with cancer. Ionizing radiation effectively inhibits the growth of cancer cells by inducing cell death and increasing anticancer immunity, through the induction of natural killer group 2 membe r D ligands (NKG2DLs); however, adverse effects have also been reported, including the promotion of metastasi...

As we enter the new millennium, population explosion, increasing worldwide energy demands and rapid global increase in ionizing radiation are all now threatening our fragile environment like no other time in known history. There is an urgent need for research and education to focus on the complex and direct link between ionizing radiation and its irreversible impact on the environment. Hence, n...

Previous studies have demonstrated that ionizing radiation induces the expression of certain cytokines, such as TNF alpha/cachectin. However, there is presently no available information regarding the molecular mechanisms responsible for the regulation of cytokine gene expression by ionizing radiation. In this report, we describe the regulation of the TNF gene by ionizing radiation in human myel...

We examined associations between low-level exposure to ionizing radiation and mortality among 14,095 workers hired at the Oak Ridge National Laboratory between 1943 and 1972. Workers at the facility were individually monitored for external exposure to ionizing radiation and have been followed through 1990 to ascertain cause of death information. Positive associations were observed between low-l...

RAD51 has critical roles in homologous recombination (HR) repair of DNA double-strand breaks (DSB) and restarting stalled or collapsed replication forks. In yeast, Rad51 function is facilitated by Rad52 and other "mediators." Mammalian cells express RAD52, but BRCA2 may have supplanted RAD52 in mediating RAD51 loading onto ssDNA. BCCIP interacts with BRCA2, and both proteins are important for R...

Deinococcus radiodurans is among a small number of bacterial species that are extremely resistant to ionizing radiation, UV light, toxic chemicals, and desiccation. We measured proteome oxidation (i.e., protein carbonylation, PC) in D. radiodurans as well as in standard and evolved resistant strains of Escherichia coli exposed to ionizing radiation or UVC light and found a consistent correlatio...