BACKGROUND The nature of dietary fats affects the postprandial activation of the hemostatic system. OBJECTIVE We investigated whether the ratio of oleic to palmitic acid [and that of monounsaturated to saturated fatty acids (MUFA:SFA)] in the diet affects postprandial concentrations of triacylglycerols, tissue factor (TF), fibrinogen, tissue-type plasminogen activator (t-PA), and plasminogen ...

OBJECTIVE Macrophage endothelial lipase (EL) is associated with increased atherosclerosis and inflammation. Because of their anti-inflammatory properties we hypothesized that n-3 fatty acids, in contrast to saturated fatty acids, would lower macrophages and arterial EL and inflammatory markers. METHODS AND RESULTS Murine J774 and peritoneal macrophages were incubated with eicosapentaenoic aci...

It is generally recognized that the pathways of fatty acid breakdown and of glucose catabolism (Embden-Meyerhof scheme) are confluent at the level of the 2-carbon fragment (acetyl-S-CoA). Nevertheless, several observations suggest an interplay between the metabolism of carbohydrate and that of fatty acids at a higher level: (a) Rats forcibly fed carbohydrate, as opposed to those fasted, exhibit...

Recently, Temme et al (1) reported the effects of feeding diets enriched in lauric, palmitic, or olcic acid on plasma lipids in 32 normocholcstcrolemic men and women. The results showed that lauric acid was more hypercholesterolemic than palmitic acid and both were hypercholesterotemic compared with olcic acid. The subjects consumed solid food diets and the authors managed an 8% of energy excha...

Cholesterol was identified as an essential component of the receptor on the sheep erythrocyte to which Rickettsia prowazeki adsorbs before lysing the cell. Erythrocytes or ghosts, derived by hypotonic lysis, were treated with proteolytic enzymes, sialidase, sulfhydryl reagents, and periodate without affecting their ability to adsorb rickettsiae. Lipid extracts of ghosts and erythrocytes, on the...

Gas chromatographic determination of the fat ty acids in the seeds of soybean (Glycine max) showed mainly linoleic, oleic and palmitic acids with linoleic acid being the major component . Changes in the distribution of fat ty acids were measured during germination in the cotyledons and roots. A decrease in palmitic and oleic acids was observed in the cotyledons from 6 to 12 days, while linoleic...

Conditions were developed for rapid deposition of triglyceride in isolated rat hepatocytes. Liver cells from fasted rats were incubated for 90 min at 37OC with 3.0 mM palmitic or oleic acid, 4 % bovine serum albumin, 20 mM glucose, 10 mM lactate, and 1 mM pyruvate. When oleic acid was used, numerous cytoplasmic lipid droplets were produced. When hepatocytes were incubated with palmitic acid, si...

Dietary fatty acids play a role in glucose homeostasis. The aim of this study was to assess the individual relationship between dietary saturated (SFA), monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids with postprandial β-cell function and insulin sensitivity in subjects with normal and high fasting triglycerides. We assessed postprandial β-cell function (by the insulinogenic index...

The epidermis of larvae of Tedania ignis (Porifera, Demospongiae) is uniformly ciliated except for the posterior pole. The epidermal cells are long, columnar, and monociliate; each cilium arises from an epidermal crypt; symbiotic bacteria were not observed in larval cells. These lecithotrophic ("nonfeeding") larvae can feed by assimilating dissolved organic materials (DOM) from seawater. Larvae...