CASE REPORT An obese 16-year-old male presented with chronic headaches and bitemporal visual field loss. Physical exam showed acanthosis nigricans and BMI of 39.8 kg/m.2 MRI of the brain revealed craniopharyngioma (Figure 1). He developed hypopituitarism after surgery, requiring Hydrocortisone, Levothyroxine, Testosterone enanthate, and desmopressin (DDAVP). Two months later, he presented with ...

described in the Japanese population, several PP cases have also been reported in Western countries and, recently, in the Middle East.2,3 Thepathogenesis of PP is not completely clear. In addition to being associated with several factors including exogenous (physical trauma, friction)andhormonal (pregnancy,menstruation),PPhasclassicallybeenreported inassociationwithmetabolic derangements, espec...

Ketosis is a metabolic disorder associated with high production and low energy intake in dairy cows. Fat reserves are mobilized, gluconeogenesis occurs. Traditionally, rapid tests for blood, milk or urine used to detect increased ketone body levels case of ketosis. Breath analysis relatively new relevant the development automatic sensor systems early warning. This study aims determine whether w...

1. Rezvani I, Rezvani GA. An approach to inborn errors of metabolism. In: Kliegman R, Stanton B, St Geme JW, Schor NF, Behrman RE, editors. Nelson Textbook of Pediatrics. 20th ed. Philadelphia: W.B. Saunders Company; 2016. p. 634‐6. 2. Burton BK. Inborn errors of metabolism in infancy: A guide to diagnosis. Pediatrics 1998;102:E69. 3. Sperling MA. Hypoglycemia. In: Kliegman R, Stanton B, St Gem...

Non-ketotic hyperglycinemia (NKH) is a rare inborn error of metabolism and is caused by a glycine cleavage system deficiency. Eighty-five percent of patients present with the neonatal type of NKH, the infants initially develop lethargy, seizures, and episodes of apnea, and most often death. Between 60-90% of cases are caused by mutations in the glycine decarboxylase (GLDC). We believed that mor...

This is the first reported case of a patient with both non-ketotic hyperglycinemia and propionic acidemia. At 2 years of age, the patient was diagnosed with non-ketotic hyperglycinemia by elevated glycine levels and mutations in the GLDC gene (paternal allele: c.1576_1577insC delT and c.1580delGinsCAA; p.S527Tfs*13, and maternal allele: c.1819G>A; p.G607S). At 8 years of age after having been p...

Djoković R., H. Šamanc, Z. Nikolić, S. Bošković Bogosavljević: Changes in Blood Values of Glucose, Insulin and Inorganic Phosphorus in Healthy and Ketotic Dairy Cows after Intravenous Infusion of Propionate Solution. Acta Vet. Brno 2007, 76: 533-539. The aim of the present study was to determine the degree of blood glucose utilization by peripheral tissue on the basis of changes in blood concen...