Carbonaceous meteorites deliver a variety of organic compounds to Earth that may have played a role in the origin and/or evolution of biochemical pathways. Some apparently ancient and critical metabolic processes require several compounds, some of which are relatively labile such as keto acids. Therefore, a prebiotic setting for any such individual process would have required either a continuou...

The experiments were designed to get some information on the metabolism controlled by variation of the NADP level, which is known to change with the variation of environmental factors.The exogenous NADP added to the mitochondria prepared from Vigna sesquipedalis cotyledons was associated with and/or penetrated into the mitochondria. The combined NADP served in the operation of the mitochondrial...

Alpha-ketoglutaric acid (A-KG) is currently under investigation as promising cancer cell damaging agent and cyanide antidote. A simple, specific liquid chromatography-mass spectrometry (LC-MS/MS) method was developed for the quantitative determination of A-KG in human plasma. Derivatization of A-KG was achieved by using N-methyl imidazole in presence of trifluroacetic anhydrate. Several paramet...

An analytical method which offers accurate determination and identification of eight α-keto acids (α-ketoglutaric acid, pyruvic acid, 4-hydroxyphenylpyruvic acid, 3-methyl-2-oxobutyric acid, α-keto-γ-methylthiobutyric acid, 4-methyl-2-oxovaleric acid, 3-methyl-2-oxovaleric acid, and phenylpyruvic acid) in pork meat and Iberian ham samples is reported. The method utilises a highly selective and ...

The levels of organic acids representing metabolic pathway end products are important indicators of physiological status, and may be associated with metabolic changes in cancer. The aim of this study is to investigate the levels of organic acids in cancerous and normal tissues from gastric cancer patients and to confirm the role of metabolic alterations in gastric carcinogenesis. Organic acids ...

The widespread use of diesel fuel for transportation, industry, and electricity generation causes several environmental issues via an increase in the amount sulfur compound emissions. Commercial must be free sulfur-containing compounds since they can cause problems. Considering currently available processes to eliminate compounds, oxidative desulfurization (ODS) is one effective means this purp...

A number of Lactobacillus strains produced succinic acid in de Man-Rogosa-Sharpe broth to various extents. Among 86 fresh isolates from fermented cane molasses in Thailand, 30 strains (35%) produced succinic acid; namely, 23 of 39 Lactobacillus reuteri strains, 6 of 18 L. cellobiosus strains, and 1 of 6 unidentified strains. All of 10 L. casei subsp. casei strains, 5 L. casei subsp. rhamnosus s...

The interrelationships of L-ascorbic acid (AsA) and dehydro-L-ascorbic acid (DHA) have been investigated both in viva and in vitro by numerous workers, with especial emphasis upon the conversion of DHA to AsA by the animal body (l-8). The conversion of DHA to diketo-L-gulonic acid (DKA) in vitro has been shown by Herbert and coworkers (3), by Borsook (l), and by Penney and Zilva (6), and this c...