Francois Malecaze MD commenced the session with an update on current research into the genetics of keratoconus. Dr Malecaze noted that forme fruste keratoconus is one of the major causes of post-LASIK corneal ectasia and the condition may be due to genetic factors in the majority of cases. Identification of the gene or genes responsible for keratoconus might lead to the development of blood tes...

Cyanide is a ubiquitous chemical in the environment and has been associated with many intoxication episodes; however, little is known about its potentially toxic effects on development. The aim of this study was to evaluate the effects of maternal exposure to potassium cyanide (KCN) during pregnancy on both sows and their offspring. Twenty-four pregnant sows were allocated into four groups that...

purpose: to determine the sensitivity and specificity of posterior corneal elevation in discriminating keratoconus and subclinical keratoconus from normal corneas by galilei and orbscan ii diagnosed on the basis of topography. methods: three groups (keratoconus, subclinical keratoconus and normal) were evaluated with galilei and orbscan ii and results were compared to those obtained by gold sta...

BACKGROUND AND OBJECTIVES The overall purpose of this study was to investigate the role of cytochrome C oxidase (CcO) in preventing ischemia reperfusion-induced cardiac injury through gaseous signaling molecule pathways. MATERIALS AND METHODS We used CcO inhibitor, potassium cyanide (KCN) to mimic the pre-treatment of gaseous signaling molecules in a global ischemia/reperfusion (IR) injury mo...

PURPOSE Keratoconic corneas exhibit more mitochondrial DNA (mtDNA) damage than do normal corneas and thus mtDNA may represent a potential candidate for genetic susceptibility studies in keratoconus. To test this hypothesis we determined mitochondrial haplogroups in Saudi patients with keratoconus and healthy controls of same ethnicity. METHODS Mitochondrial haplogrouping was performed by poly...

Cupferron, the ammonium salt of N-nitro-sophenylhydroxylamine, enhances the frequencies of structural chromosome changes produced by x-rays in the root tips of the broad bean, Vicia faba (7, 4-6). The enhancement produced at low oxygen pressures (0.3 to 5 per cent 02 in the gas phase) is particularly striking and appears to be a result of the inhibitory action of cupferron on oxygen consumption...

Product quality problems are becoming increasingly complex with the increasing richness of product types and functions, making it challenging to solve only personal knowledge effectively. Thus, we propose an approach extract solution from problem-solving data improve efficiency problem-solving. Specifically, by analyzing characteristics data, a method for calculating membership degree nodes is ...

ABSTRACT Cyanide (KCN) and paraquat (PQ) are very toxic to mitochondria. In this study the toxicity of KCN and PQ in the isolated rat liver mitochondria was determined using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay and JG-B (Janus green B) assay by multiwell scanning spectrophotometry. JG-B was used not only for the vital staining of mitochondria, but also fo...

PURPOSE To determine the prevalence and risk factors for sleep apnea in a keratoconus population. METHODS Ninety-two keratoconus patients and 92 controls were classified as high risk or low risk for sleep apnea, using the Berlin Questionnaire (BQ) or individual history of sleep apnea. Logistic regression was used to investigate the risk factors associated with high risk of sleep apnea in kera...

Keratoconus is an ectatic corneal dystrophy associated with stromal thinning and disruption of Bowman's layer. The purpose of this study was to explore a possible association between keratocyte apoptosis and keratoconus. Keratocyte apoptosis was evaluated in corneas of patients with keratoconus, corneas of patients with stromal dystrophies, and normal donor corneas using the transferase-mediate...