A case-control study was conducted to evaluate the association between knee osteoarthritis (OA) and physical activity (PA) among a community group aged 40 years and older. Case patients (85 males, 154 females) had radiologically confirmed knee OA with grade 2+ changes, according to Kellgren and Lawrence criteria. Control subjects (85 males, 154 females) had no radiologic evidence of knee OA. A ...

INTRODUCTION Post-traumatic osteoarthritis (PTOA) is the unfortunate outcome of many high-energy fractures of the tibial plafond. The severity of the fracture is a major risk determinant. The inability to objectively quantify fracture severity has confounded efforts to determine the efficacy of different treatments aimed at preventing the PTOA development. A CTbased measure of fracture energy w...

Our aim in this longitudinal study was to evaluate to what extent fat and lean tissue mass variations are associated and can predict RKOA in a large sample of British women followed-up over 10 years. Kellgren/Lawrence (K/L), joint space narrowing (JSN) and osteophyte (OSP) grades were scored from radiographs of both knees in 909 middle-aged women from the Chingford registry. Body composition co...

It has been suggested that arthrodesis of the ankle leads to osteoarthritis of the joints of the ipsilateral hind- and midfoot. We believe these studies overlooked the presence of osteoarthritic changes in these joints before the arthrodesis. We reviewed the pre-operative radiographs of 70 patients with osteoarthritis of the ankle who underwent 71 ankle arthrodeses (one was bilateral). The talo...

This study examined the contribution of the osteoarthritis (OA) susceptibility genes ASPN, GDF5, DIO2, and the 7q22 region to the development of radiographic knee OA in patients with a mean age of 40.6 ± 7.9 years (standard deviation) and who suffered from nonacute knee complaints a decade earlier. Dose-response associations of four single nucleotide polymorphisms(SNPs) in the susceptibility ge...

BACKGROUND The aim of this study was to evaluate the role of interleukin-17 (IL-17) level in synovia and its relationship with the severity of knee osteoarthritis (OA). MATERIAL AND METHODS We enrolled 226 OA patients and 106 controls in this study. The symptomatic/radiation severity of OA was assessed by the Western Ontario McMaster University Osteoarthritis Index (WOMAC) pain score/Kellgren...

OBJECTIVE To examine the association between hand and knee osteoarthritis (OA) in a community based population. METHODS Radiographs of 695 participants aged > or = 40 years in the Baltimore Longitudinal Study of Aging were read for changes of OA, using Kellgren-Lawrence grade > or = 2 as the case definition. RESULTS Logistic regression analyses, adjusting for age, gender and body mass index...

Knee osteoarthritis (OA) is a usual problem in the elderly population, which treated with lifestyle modifications, non-steroidal anti-inflammatory drugs, physiotherapy, and intraarticular injections of corticosteroids/hyaluronic acid/autologous platelet-rich plasma (PRP) early stages, late surgical procedures, such as arthroscopic debridement, unicompartmental arthroplasty, patellofemoral total...