Abstract Glioblastoma (GBM) represents a particularly aggressive and immune-resistant cancer. Preclinical investigations have identified the anti-tumor activity of ketogenic diet (KD) in GBM, potentially being used as tool to target its glycolytic phenotype. Since immune cells tumor similar reliance upon nutrients perform their individual functions, we sought determine if KD influenced landscap...

Ketogenic (KD) and high-fat (HFD) diets vitamin D (VD) produce variable effects on insulin secretion body weight (BW), but mechanisms remain unclear. We investigated the of normal fat (NFD), KD, HFD with without VD BW serum glucose, insulin, VD, resistance, C-reactive protein, interleukin-6, tumor necrosis factor-alpha in rats. Three isocaloric NFD, containing respectively protein-carbohydrate-...

The ketogenic diet (KD), a restrictive diet, is mainly characterized by high-fat content, low or no carbohydrate and normal protein content. This review aimed to address the main syndromes diseases in which therapeutic use of KD can be beneficial. One clinical indications has been, for some time, treatment epilepsy refractory medications, with satisfactory results control seizures. Recently, st...

Since the coronavirus disease 2019 (COVID-19) outbreak started, children have been considered marginally involved compared to adults, with a quite significant percentage of asymptomatic carriers. Very recently, an overwhelming inflammatory activation, which shares clinical similarities Kawasaki (KD), has described in exposed COVID-19. We report three KD-like cases that occurred during pandemic ...

Case presentation: We conducted a descriptive study of 4 cases with GLUT1 Deficiency (Glut1D) diagnosed in our service the past 2 years. The diagnosis was established by: hypoglycorrhachia, clinical symptoms and SLC2A1 mutation. Our first patient, 4-year-old boy, presented developmental delay, hypotonia, myoclonic jerks drop attacks at 11 months age. MRI brain image showed bilateral hippocampal...

BACKGROUND A low-carbohydrate, high-fat ketogenic diet (KD) induces hepatic ketogenesis and is believed to affect energy metabolism in mice. As hepatic Fgf21 expression was markedly induced in mice fed KD, we examined the effects of KD feeding on metabolism and the roles of Fgf21 in metabolism in mice fed KD using Fgf21 knockout mice. METHODOLOGY/PRINCIPAL FINDINGS We examined C57BL/6 mice fe...