Oxidative stress may play an important role in the pathogenesis of keratoconus (KC). Mitochondrial DNA (mtDNA) is involved in mitochondrial function, and the mtDNA content, integrity, and transcript level may affect the generation of reactive oxygen species (ROS) and be involved in the pathogenesis of KC. We designed a case-control study to research the relationship between KC and mtDNA integri...

Recently, environment-friendly synthesis of gold nanoparticles (GNPs) has been extensively explored by biologists and chemists. However, significant research is still required to determine whether "eco-friendly" GNPs are beneficial to human health and to elucidate the molecular mechanisms of their effects on human cells. We used human neuronal SH-SY5Y cells to show that treatment with Kalopanac...

The effects of the anaphylatoxins C5a and C3a on the liver are only poorly characterized in contrast to their well known systemic actions. Recently, it has been demonstrated that the anaphylatoxin C5a enhanced glucose output from hepatocytes (HC) indirectly via prostanoid release from Kupffer cells (KC). In the present study, it is shown that recombinant rat C5a (rrC5a), together with LPS, acti...

The murine chemokine CXCL1/KC is known as a chemoattractant for neutrophil infiltration and as a promoter of tumor growth. To determine its relevance in tumorigenesis, we first asked whether okadaic acid (OKA), a natural tumor promoter and a potent protein phosphatase 1 and 2A inhibitor, stimulates KC expression and if it does, through what pathway, in a promotable mouse epidermal-like JB6 cell...

BACKGROUND A previous study revealed elevated serum Immunoglobulin E (IgE) in ketamine related cystitis (KC) patients. IgE might participate the pathogenesis of different types of bladder pain syndromes, including KC and interstitial cystitis (IC). OBJECTIVES To investigate the IgE expression in KC and IC bladder tissue. STUDY DESIGN Prospective evaluation. SETTING The study was conducted...

INTRODUCTION Keratoconus (KC) is a non-inflammatory thinning of the cornea and a leading indication for corneal transplantation. Oxidative stress plays a role in the pathogenesis of this disease. The products of the hOGG1 and MUTYH genes play an important role in the repair of oxidatively modified DNA in the base excision repair pathway. We hypothesized that variability in these genes may chang...

IMPORTANCE Patients with basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) (often termed nonmelanoma skin cancer or keratinocyte carcinoma [KC]) often develop new KCs, but information is limited on the frequency and timing of these subsequent tumors. This information is crucial to guide follow-up care. OBJECTIVE To determine the timing of subsequent new KCs in patients wh...

Under the Castor earthquake, there is a risk of liquefaction instability saturated tailings, and evolution dynamic pore pressure can indirectly reflect its process. Before applying loads, static stress state soil one main factors affecting development strength pressure, are significant differences in under different consolidation ratios. This paper conducted triaxial tests on tailings silt with...

this study is carried out to estimate the potential evapotranspiration (pet) and crop coefficient (kc) for wheat, bl 3235 variety. a lysimeter is installed to estimate pet at the experimental farm of agricultural research center of bhairahawa, which is located in western part of nepal. the blaney-criddle formula is used to estimate the kc for wheat. the estimated values of pet and kc for wheat ...

the present study was undertaken to investigate the role of banana extract (be) on synchronous plantlet formation from seeds of dendrobium lituiflorum lindl. the seedlings formed on modified knudson c (kc) medium supplemented with 20% (v/v) be had significantly high fresh and dry weights. morphologically uniform plantlets with elongated leaves and well developed roots were formed on kc medium w...