Ascending cholangitis occurs in about 30 to 50% of patients after Kasai hepatoportoenterostomy for extrahepatic biliary atresia (1,2). It generally occurs within the first few years after surgery (3). Late cholangitis seems to be extremely rare (3,4). Patients with cholangitis usually have high fever with chills and jaundice, reflecting worsening of liver functions in about half of the patients...

Although biliary obstruction in extrahepatic biliary atresia (EHBA) patients can be surgically alleviated by hepatoportoenterostomy (Kasai surgery), most patients will eventually develop severe hepatic fibrosis with short life expectancy. Cellular and molecular mechanisms involved in this process are largely unknown. The aim of this study was to determine the potential correlation between fibro...

PURPOSE The purpose of this study was to define the role of cyclooxygenase-2 inhibitors (COX-2i) in reducing hepatic fibrosis in pediatric patients with chronic liver disease. MATERIALS AND METHODS From September 2009 to September 2010, patients over 2 years old who visited our outpatient clinic for follow-up to manage their chronic liver disease after Kasai portoenterostomy for biliary atres...

Biliary atresia is a rare neonatal disease of unknown etiology, where obstruction of the biliary tree causes severe cholestasis, leading to biliary cirrhosis and death in the first years of life, if the condition is left untreated. Biliary atresia is the most frequent surgical cause of cholestatic jaundice in neonates and should be evoked whenever this clinical sign is associated with pale stoo...

Les publications de Rik Ceyssens, anthropologue dont le terrain privilegie est la region du Kasai en Republique democratique Congo, sont bien connues des historiens qui se interesses a periode fin XIXe siecle, lorsque structures etatiques deconstruites et reconstruites Afrique centrale, notamment sous l’action Balungu, pour citer un essai publie par l’auteur 1998. L’ouvrage il question ici rele...

Biliary Atresia (BA), a result from inflammatory destruction of the intrahepatic and extrahepatic bile ducts, is a severe hepatobiliary disorder unique to infancy. Early diagnosis and Kasai operation greatly improve the outcome of BA patients, which encourages the development of early screening methods. Using HPLC coupled tandem mass spectrometry, we detected primary bile acids content in dried...

Biliary atresia (BA), a uniquely pediatric liver disease, is the leading cause of liver-related death in children and the most frequent indication for liver transplantation in the pediatric population. Early intervention with a Kasai procedure (KP) is the current standard of care for this condition. The single most important and well-established prognostic factor for the KP outcome is the patie...

INTRODUCTION Biliary atresia is the leading cause of liver transplantation in children. It affects 1:15,000 in Denmark. With a national birth rate of 60,000, four children are born every year with biliary atresia. Early correction of biliary obstruction is essential to prevent fatal biliary cirrhosis. The Danish Health and Medicines Authority (DHMA) demands diagnostic evaluation of children wit...

Biliary atresia (BA) is an obliterative cholangiopathy affecting 1:10.000-14.000 of newborns. Infants with Biliary Atresia Splenic Malformation syndrome (BASM) are a subgroup of BA patients with additional congenital anomalies. Untreated the disease will result in fatal liver failure within the first years of life. Kasai portoenterostomy restores bile flow and delay the progressive liver damage...