cartilage is an avascular, aneural, and alymphatic connective tissue with a limited capacity caused by low mitotic activity of its resident cells, chondrocytes. natural repair of full thickness cartilage defects usually leads to the formation of fibrocartilage with lower function and mechanical force compared with the original hyaline cartilage and further deterioration can occur. tissue engine...

background: engineering new bone tissue with cells and a synthetic extracellular matrix represents a new approach for the regeneration of mineralized tissues compared with the transplantation of bone (autografts or allografts). methods: in this study, to mimic the mineral and organic component of natural bone, hydroxapatite (ha) and gelatin (gel) composite scaffolds were prepared. the raw mater...

conclusions this was the first study that focused on expanding resilience indicators, and presents a new framework to simplify assessment of resilience and safety of a complex system. results in this study, 29 factors affecting this indicator were determined using the delphi method; the scores of all factors were less than the scores of the best practice. on the other hand, the state of this in...

Articular cartilage, the load-bearing tissue of the joint, has limited repair and regeneration ability. The scarcity of treatment modalities for large chondral defects has motivated researchers to engineer cartilage tissue constructs that can meet the functional demands of this tissue in vivo. Cartilage tissue engineering requires 3 components: cells, scaffold, and environment. ...

Tissue engineering is based on three main factors including scaffolds, cells and growth factors. Natural scaffolds derived from decellularized tissues and organs have been successfully used in tissue engineering. Decellularization studies have shown that natural scaffolds which maintaine their main structure and properties could be a suitable tool for studying cellular behaviors and preparation...

not available

we report engineering experiences from the critical task of relief well installation under high artesian flow conditions at the downstream toe of the karkheh earth dam, iran. due to the establishment of excessive uplift pressure at the downstream toe of the karkheh dam, installation of a series of new relief wells was considered to permanently relieve part of these pressures. the mentioned upli...

System engineering is one of the most powerful tools for comprehensive project management and control. This tool emphasized the life cycle of the projects, manages every single activity and helps manage the main elements of the project through a set of management and engineering processes. The goal of the current study is to use a system engineering approach in design phase in order or to meet ...