The world has lost one of its great scientists and the University of California its most influential educator with the death of Daniel E. Koshland, Jr. on Monday, July 23, 2007. Dan’s career spanned 60 years of creative biochemical research, and he was actively planning his next experiments on the Friday before his sudden death. Those of us fortunate enough to have experienced Dan’s extraordina...

W hile a PhD candidate, doing my thesis at the Oak Ridge National Laboratory, Biology Division under Dr. Charles Congdon, my introduction to the immune response was studying graft vs. host (GVH) disease as a consequence of bone marrow transplantation in mice. The sequalae of GVH was impressive, and demonstrated the potential of negative clinical consequences of the immune system. The idea of ha...