Narcosis is a nonspecific reversible state of arrested activity of protoplasmic structures caused by a wide variety of organic chemicals. The vast majority of industrial organic chemicals can be characterized by a baseline structure-toxicity relationship as developed for diverse aquatic organisms, using only the n-octanol/water partition coefficient as a descriptor. There are, however, many app...

Pollinators in agricultural landscapes can be exposed to mixtures of pesticides and environmental pollutants. Existing mixture toxicity modelling approaches, such as the models of concentration addition and independent action and the mechanistic DEBtox framework have been previously shown as valuable tools for understanding and ultimately predicting joint toxicity. Here we apply these mixture m...

In this paper we will present an immersive multiuser environment for studying joint action and social interaction. Besides the technical challenges of immersing multiple persons into a single virtual environment, additional research questions arise: Which parameters are coordinated during a joint action transportation task? In what way does the visual absence of the interaction partner affect t...

the use of adjuvants enhances the insecticide efficiency and increases the persistence of insecticides. in this study, the effect of adjuvants on the toxicity of chlorpyrifos and cyhalothrin formulations were investigated under laboratory and field conditions. the comparative toxicity of two chlorpyrifos [(48% emulsifiable concentrate (ec)] formulations (dursban and pyrifos el nasr), two cyhalo...

A phase I/II clinical trial design is proposed for adaptively and dynamically optimizing each patient's dose in each of two cycles of therapy based on the joint binary efficacy and toxicity outcomes in each cycle. A dose-outcome model is assumed that includes a Bayesian hierarchical latent variable structure to induce association among the outcomes and also facilitate posterior computation. Dos...

nowadays herbicide reduction and different approaches leading to this goal like split application have been brought to attention. two green house experiments were carried out to investigate the efficiency of single and split application of mesosulfuron-methy+iodosulfuron methyl to control wild oat (avena ludoviciana). the influence of applications intervals and the ratios of the two application...