BACKGROUND Although several studies show that JIA-patients have significantly lower employment rates than the general population, the research on educational and occupational attainments in patients with juvenile idiopathic arthritis (JIA) remain conflicting most likely due to small sample sizes. Therefore, aim of this study is to compare the educational achievements and employment status of 36...

Background Oligoarticular JIA is presently unpredictable in its course and can become more severe after an initially mild onset. We examined the cellular and molecular composition of the first synovial fluid (SF) aspirates from oligoarticular JIA patients to discover markers that predict an increase in number of joints involved and thus, extension to more severe phenotype (extended oligoarticul...

Results 20 patients with JIA had an articular form, 11 children had an systemic form. 2 patients had diffuse form of systemic sclerosis (SS). 6 patients had a limited form of SS. 8 children had scleroderma. 8 children with JS, 13 children with JIA and all children with SLE had fever, weakness, weight loss at the onset of the disease. 3 children with JS, 12 children with JIA and 5 with SLE had l...

Introduction Uveitis is the most common extraarticular manifestation of juvenile idiopathic arthritis (JIA). The nature of JIAassociated uveitis is often insidious and asymptomatic, and baseline predictors can aid early diagnosis of eye disease for prompt and adequate treatment. Antihistone antibodies (AHA) are among subtypes of antinuclear antibodies (ANA) identified in children with JIA. An a...

Introduction Juvenile idiopathic arthritis (JIA) is the most common arthritis disease of childhood and is an important cause of disability. Methotrexate (MTX) is the mainstay treatment in JIA. Unfortunately, 30-35% of patients fail to respond MTX, and the delay in identifying the optimal treatment at an early stage of disease can lead to longterm joint damage. Recent studies have evaluated comp...

BACKGROUND A chronic illness, such as Juvenile Idiopathic Arthritis (JIA), has an impact on the whole family, especially on parents caring for the ill child. Therefore the aim of this study is to evaluate parental Health Related Quality of Life (HRQOL) and parental perceptions of child vulnerability (PPCV) and associated variables in parents of a child with JIA. METHODS Parents of all JIA pat...

Juvenile idiopathic arthritis (JIA) is a heterogeneous autoimmune disease characterized by chronic joint inflammation. Knowing which antigens drive the autoreactive T-cell response in JIA is crucial for the understanding of disease pathogenesis and additionally may provide targets for antigen-specific immune therapy. In this study, we tested 9 self-peptides derived from joint-related autoantige...

BACKGROUND Youth with juvenile idiopathic arthritis (JIA) may be at risk of poor cardiovascular health. Circulating endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) are markers of cardiovascular repair and damage, respectively, and respond to exercise. The objectives of this study were to compare resting levels of EPCs and CECs in JIA and controls, and to assess the ...

INTRODUCTION Juvenile idiopathic arthritis (JIA) is a heterogeneous group of inflammatory diseases of joints in children with various and often unfavourable prognosis. It is possible to improve the outcome of the disease in patients with JIA by a correct therapeutic choice made at disease onset - one that enables fast achievement of an inactive disease state and remission. The aim of the invest...