The funding for this research was provided by the Rockefeller Foundation and the EVALUATION Project. The survey used in this study could not have been completed without the cooperation and assistance of the community of international donors, NGOs, local government officials, and the Philippines Department of Health. Their cooperation and generosity with their expertise are much appreciated. We ...

1 Center for Advancing Materials Performance from the Nanoscale (CAMP-Nano) & Hysitron Applied Research Center in China (HARCC), State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China 2 State Key Laboratory of Electrical Insulation and Power Equipment, Xi’an Jiaotong University, Xi’an 710049, China 3 Department of Nuclear Science and Engineerin...

AIM Sledge jump systems (SJS) are often employed to examine the underlying mechanical and neuromuscular mechanisms of the stretch-shortening cycle (SSC) as they allow the systematic variation of impact velocity and energy. However, in existing SJS the jumps are not very comparable to natural jumps because of the long contact times (∼200%), which prevent the storage of kinetic energy. The aim of...

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare mucocutaneous, unpredictable, life-threatening drug side reactions. A very rare case of norfloxacin-induced SJS/TEN overlap with uncommon clinical presentation in a patient with a suspected urinary tract infection is reported. The SJS/TEN management with possible treatment capabilities are discussed. In spite of only t...

To the best of our knowledge, Stevens-Johnson syndrome (SJS) has not been reported previously as an adverse reaction to Malarone, which is a combination of atovaquone and proguanil hydrochloride used for antimalarial prophylaxis and therapy. We describe a 65-year-old patient who had SJS with typical clinical and histopathological findings associated with the use of Malarone prophylaxis for mala...

BACKGROUND Intravenous immunoglobulin (IVIG) treatment is commonly used to treat Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with controversial therapeutic effect. METHODS We conducted a comprehensive meta-analysis through combining the published eligible studies to evaluate the effectiveness of IVIG on SJS and TEN treatment. RESULTS A total of 26 studies were select...

BACKGROUND Stevens-Johnson syndrome (SJS) is an acute life-threatening condition often elicited by drugs. The government's indecisiveness in deciding to stop the use of nevirapine (NVP) in HIV-infected pregnant women owing to the increase of SJS among this population group in South Africa prompted this investigation. OBJECTIVES To investigate if pregnancy is a risk factor for SJS among HIV-in...

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN, Lyell's disease) are severe, episodic, acute mucocutaneous reaction that may be caused by various factors particularly drugs. Treatment is primarily supportive care and there are no specific therapy regimens. Intravenous immunoglobulin (IVIG) has recently been shown to be a useful and safe therapy in paediatric patients with SJ...

The presence of HLA-B*15:02 allele greatly increases the risk of carbamazepine-induced severe cutaneous adverse drug reactions, namely Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).1,2 It is unknown whether HLA-B*15:02 also confers increased risk of SJS/TEN induced by other anti-epileptic drugs (AEDs). HLA-B*15:02 in single cases of SJS/TEN is reported to be induced by phe...