The transcription of ribosomal RNA (rRNA) is critical to life. Despite its importance, ribosomal DNA (rDNA) is not included in current genome assemblies and, consequently, genomic analyses to date have excluded rDNA. Here, we show that short sequence reads can be aligned to a genome assembly containing a single rDNA repeat. Integrated analysis of ChIP-seq, DNase-seq, MNase-seq and RNA-seq data ...

The internal transcribed spacer (ITS) of the ribosomal DNA is generally considered to be under low functional constraint, and it is therefore often treated as a typical nonfunctional spacer sequence. We have analyzed the ITS regions of five species from the Drosophila melanogaster subgroup, two Drosophila species from outside this group (D. pseudoobscura and D. virilis), as well as from the mor...

Abstract The Fairlie-Gumbel-Morgenstern (FGM) family has been investigated in detail for various continuous marginals such as Cauchy, normal, exponential, gamma, Weibull, lognormal and others. It has been a popular model for the bivariate distribution with mild dependence. However, bivariate FGM’s with continuous marginals on a bounded support discussed in the literature are only those with uni...

Abstract We give some adequate extension, in the framework of a general Lévy process, of our previous construction of processes with one-dimensional martingale marginals, done originally in the set-up of Brownian motion. The Lévy process framework allows us to streamline our previous arguments, as well as to reach a larger class of such processes, even in the Brownian case. We give some illustr...