AbstractThis paper examines the impasse in the current Doha Development Round negotiations andasks how the rules of the WTO could be changed to facilitate multilateral negotiations andto increase the welfare of the Member countries. It considers possible changes to the methodof negotiation. As examples of rules which are outdated, it considers the rules relating toregional trade agreements and ...

periodontal disease is a chronic inflammatory disease which represents a primarily anaerobic gram‑negative oral infection that results in gingival inflammation, loss of attachment, bone destruction. bacterial endotoxins in the form of lipopolysaccharides (lps) that are instrumentalin generating a host‑mediated tissue destructive immune response by mobilizing their defensivecells and releasing c...

We present two cases of segmental arterial mediolysis, which can present with dissecting aneurysms or thrombosis of the visceral branches of the abdominal aorta. Segmental arterial mediolysis (SAM) causes ischemic bowel disease and has characteristic CT and angiographic features.

End-stage renal disease (ESRD) is characterized by an exceptional mortality rate, much of which is the result of cardiovascular disease (CVD). Although traditional risk factors are common in ESRD patients, they may not be sufficient alone to account for the high prevalence of CVD in this condition. Recent evidence demonstrates that chronic inflammation, a non-traditional risk factor which is ob...

Longitudinal studies of human leucocyte telomere length often report a percentage of individuals whose telomeres appear to lengthen. However, based on theoretical considerations and empirical data, Steenstrup et al. (Nucleic Acids Research, 2013, vol 41(13): e131) concluded that this lengthening is unlikely to be a real biological phenomenon and is more likely to be an artefact of measurement e...

Acute aortic dissection is a potentially lethal vascular emergency that involves the rapid development of a false blood channel within the media of the aorta. If left untreated, approximately 50% of patients die in the first 48 hours, and the mortality rate increases by 1% to 3% per hour [1,2]. Despite recent advances in diagnostic methods, misdiagnosis occurs in 25%-50% of patients on initial ...