Sera from patients with myocardial infarction and cardiac arrhythmias were analyzed for myoglobin concentration and the activities of total creatine kinase, creatine kinase isoenzyme-2, and lactate dehydrogenase isoenzyme-1 at the time of hospital admission and during the first few days of hospitalization. The nine patients with a final diagnosis of myocardial infarction had abnormally high val...

The clinical significance of ST-segment changes and of the time course of appearance in serum of different cardiac proteins has been reviewed for the diagnosis of coronary reperfusion and reocclusion after thrombolysis. In particular, the value of serial 12-lead electrocardiographic (ECG) studies, of Holter monitoring, and of continuous multilead computer-assisted ECG monitoring is compared. Re...

The MB isoenzyme of creatine kinase (EC 2.7.3.2) may be prepared in vitro by dissociation of the MM and BB dimers into the M and B monomers. These monomers then recombine in a random manner to form all possible combinations-MM, MB, and BBthe presence of which may be detected by chromatography or electrophoresis. Dawson et al. (1) describe this process for animal tissues, while Keutel et a!. (2)...

Serum adenylate kinase (AK) activity was measured in cerebral vascular diseases and the AK isoenzyme pattern was studied in the patients suffering from cerebral infarction, cerebral hemorrhage, myocardial infarction, and polymyositis. There was a significant difference in AK activity between the control subjects and patients with acute cerebral infarction. Serum AK activity showed a peak on the...

The enzyme creatine kinase (CK) [EC 2.7.3.2] is a dimeric molecule consisting of two separate subunits Band M, giving rise to three isoenzymes CK-BB, CK-MB and CK-MM. Most of the CK found in the plasma of normal individuals is the MM isoenzyme derived from skeletal muscle, while the CK-MB fraction originates predominately from cardiac muscle. Normally there is little, if any, CK-BB isoenzyme pr...

I measured total creatine kinase (CK; EC 2.7.3.2) activity and isoenzyme pattern in normal and neoplastic tissues. CK activity was detected in all of them examined. In various tumors it was greater than, less than, or the same as that in normal tissue, no clear correlation being seen between total activity and growth rate or degree of differentiation. In several cases, there was a greater propo...

The interference of atypical creatine kinase (CK; EC 2.7.3.2) with anion-exchange methods for the measurement of the CK-MB isoenzyme is now firmly established. False-positive results from this source are much more common than interferences caused by the BB isoenzyme. Atypical CK, at least in some patients, does not appear to be a genetic variant, nor could we relate it to a specific clinical di...