The reactivities of 5,5’-Dithiobis (2-nitrobenzoate) with the sulphydryl groups of major haemoglobin of duck (Anas platyrhinchos) have been carried out in the presence of inositol hexakisphosphate, inositol-P6. The time course of the reaction is biphasic. The addition of inositol-P6 changed the pH dependence profile of the apparent second-order rate constant of both oxyand carbonmonoxyhaemoglob...

To investigate the role of insulin receptor substrate 1 (IRS-1) and IRS-2, the two ubiquitously expressed IRS proteins, in adipocyte differentiation, we established embryonic fibroblast cells with four different genotypes, i.e., wild-type, IRS-1 deficient (IRS-1(-/-)), IRS-2 deficient (IRS-2(-/-)), and IRS-1 IRS-2 double deficient (IRS-1(-/-) IRS-2(-/-)), from mouse embryos of the corresponding...

The proteolytic processing of human immunodeficiency virus (HIV) particles mediated by the viral pol-encoded protease (PR) is essential for viral infectivity. The pol coding sequence partially overlaps with the gag coding sequence and is translated as a Gag-Pol polyprotein precursor. Within Gag-Pol, the C-terminal p6(gag) domain is replaced by a transframe peptide referred to as p6*, which sepa...

Insulin promotes adipocyte differentiation via a complex signaling network involving multiple insulin receptor substrates (IRSs). In cultured brown preadipocytes, expression of IRS-1 and IRS-2 mRNAs and proteins was at relatively high levels before and after differentiation into mature fat cells, while IRS-3 transcript was not detectable in preadipocytes but increased during the course of diffe...

BACKGROUND Insulin resistance is associated with atherosclerosis, but its mechanism is unknown. It has been reported that insulin receptor substrate (IRS)-1 deficient (IRS-1-/-) mice showed insulin resistance without type 2 diabetes, whereas the IRS-2 deficient (IRS-2-/-) mice showed insulin resistance with type 2 diabetes. METHODS AND RESULTS We investigated neointima formation in the IRS-1-...

We present P6, a declarative language for building high performance visual analytics systems through its support specifying and integrating machine learning interactive visualization methods. As data analysis methods based on artificial intelligence continue to advance, solution can leverage these better exploiting large complex data. However, with is challenging. Existing programming libraries...

An investigation was carried out at the Research Farm of Olericulture Division of Horticulture Research Centre of Bangladesh Agricultural Research Institute (BARI) to evaluate the heterotic performance in F1 generation of tomato. The hybrids showed significant variation in heterosis. The highest heterobeltiotic effects were observed in the cross P3 x P8 (-18.46%) for earliness, P1 x P6 (8.57 %)...

In this paper we will study the complexity of 4-colorability in subclasses of P6-free graphs. The well known k-colorability problem is NP -complete. It has been shown that if k-colorability is solvable in polynomial time for an induced H-free graph, then every component of H is a path. Recently, Huang [11] has shown several improved complexity results on k-coloring Pt-free graphs, where Pt is a...

The effects of acupuncture on health are generally hard to assess. Stimulation of the P6 acupuncture point is used to obtain an antiemetic effect and this provides an excellent model to study the efficacy of acupuncture. Thirty-three controlled trials have been published worldwide in which the P6 acupuncture point was stimulated for treatment of nausea and/or vomiting associated with chemothera...