We present an analysis of XMM-Newton and RXTE data from three observations of the neutron star LMXB 4U 1636-536. The X-ray spectra show clear evidence of a broad, asymmetric iron emission line extending over the energy range 4–9 keV. The line profile is consistent with relativistically broadened Fe K-α emission from the inner accretion disk. The Fe K-α line in 4U 1636-536 is considerably broade...

Following the CMS Cathode Strip Chamber Beam Test of Summer 2004, experimental validation of the performance of CMS Track-Finder Trigger is necessary. This study focuses on the analysis of the beam profile, φ distribution fits, the beam scattering due to iron blocks in the muon beam path, and the comparison of the Track-Finder Trigger hardware output to a software simulation. Employing statisti...

Deferitrin (GT-56-252) is the first drug in a class of desferrithiocin-derived hexadentate iron chelators. Genzyme Corp is developing this compound as an oral drug for the treatment of severe iron overload in people who require repeated erythrocyte transfusion for management of chronic anemia such as beta-thalassemia major. In phase I trials in adults with beta-thalassemia, deferitrin promoted ...

Received 1/17/2005; revised 3/26/2005; accepted 4/1/2005. For correspondence or reprints contact: Chin-Ho Tsao, M.D., Division of Nuclear Medicine, Mackay Memorial Hospital, 92 Section 2, Chung-Shan North Road, Taipei 104, Taiwan. Tel: (886)2-25433535 ext. 2241, Fax: (886)2-25433535 ext. 2925, E-mail: [email protected] A 60-year-old male complained of progressing pale and jaundice in re...

Lower levels of circulating iron have been associated with depression. Our objective was to investigate the phenotypic and genetic relationship between measures of circulating levels of iron (serum iron, transferrin, transferrin saturation, and ferritin) and depressive symptoms. Data were available from ongoing studies at QIMR Berghofer Medical Research Institute (QIMRB), including twin adolesc...

Sucroferric oxyhydroxide (VELPHORO) is a polynuclear iron-based phosphate binder recently approved for the treatment of hyperphosphataemia in patients with chronic kidney disease (CKD). As a number of the available phosphate binders do not provide the optimal combination of good efficacy, adequate tolerability and low pill burden, sucroferric oxyhydroxide constitutes a promising alternative. Am...

BACKGROUND Administration of ferric pyrophosphate citrate (FPC, Triferic™) via hemodialysate may allow replacement of ongoing uremic and hemodialysis-related iron losses. FPC donates iron directly to transferrin, bypassing the reticuloendothelial system and avoiding iron sequestration. METHODS Two identical Phase 3, randomized, placebo-controlled trials (CRUISE 1 and 2) were conducted in 599 ...

BACKGROUND Iron deficiency is the most common disorder in the world, affecting approximately 25% of the world`s population and the most common cause of anemia. OBJECTIVE To evaluate the efficacy and safety of intravenous iron sucrose (IS) in the treatment of adults with iron deficiency anemia METHODS Eighty-six adult patients with iron deficiency anemia, who had intolerance or showed no eff...

A growing body of evidence suggests that macrophage polarization dictates the expression of iron-regulated genes. Polarization towards iron sequestration depletes the microenvironment, whereby extracellular pathogen growth is limited and inflammation is fostered. In contrast, iron release contributes to cell proliferation, which is important for tissue regeneration. Moreover, macrophages consti...