BACKGROUND Different superparamagnetic iron oxide nanoparticles have been tested for their potential use in cancer treatment, as they enter into cells with high effectiveness, do not induce cytotoxicity, and are retained for relatively long periods of time inside the cells. We have analyzed the interaction, internalization and biocompatibility of dimercaptosuccinic acid-coated superparamagnetic...

PURPOSE Cell-surface receptor-targeted magnetic iron oxide nanoparticles provide molecular magnetic resonance imaging contrast agents for improving specificity of the detection of human cancer. EXPERIMENTAL DESIGN The present study reports the development of a novel targeted iron oxide nanoparticle using a recombinant peptide containing the amino-terminal fragment of urokinase-type plasminoge...

Over loading of iron oxide nanoparticles can causes the liver injury through overproduction of free radicals. Zataria multiflora Boiss. (Lamiaceae) has been used for many years in folk medicine due to its antioxidant and antibacterial activities. This study evaluates -for the first time- the effect of Z. multiflora essential oil (EO) against iron oxide nanoparticles hepatotoxicity in rat model....

The use of nanoparticles in medicine is an attractive proposition. In the present study, zinc oxide and silver nanoparticles were evaluated for their antidiabetic activity. Fifty male albino rats with weight 120 ± 20 and age 6 months were used. Animals were grouped as follows: control; did not receive any type of treatment, diabetic; received a single intraperitoneal dose of streptozotocin (100...

zinc oxide (zno) nanopowders were synthesized by the sol–gel method from an ethanol solution of zinc sulfate heptahydrate in the presence of diethylene glycol surfactant. detailed structural and microstructural investigations were carried out using x-ray diffraction (xrd), high-resolution transmission electron microscopy (hrtem), field emission scanning electron microscopy (fe-sem), fourier tra...

objective: the label and detection of cells injected into target tissues is an area of focus for researchers. iron oxide nanoparticles can be used to label cells as they have special characteristics. the purpose of this study is to examine the effects of iron oxide nanoparticles on human-derived amniotic membrane stem cell (hamcs) survival and to investigate the magnetic properties of these nan...

A multitude of nanoparticles, such as titanium oxide (TiO2), zinc oxide, aluminum oxide, gold oxide, silver oxide, iron oxide, and silica oxide, are found in many chemical, cosmetic, pharmaceutical, and electronic products. Recently, SiO2 nanoparticles were shown to have an inert toxicity profile and no association with an irreversible toxicological change in animal models. Hence, exposure to S...

Dendritic cell-based cancer immunotherapy requires tumour antigens to be delivered efficiently into dendritic cells and their migration to be monitored in vivo. Nanoparticles have been explored as carriers for antigen delivery, but applications have been limited by the toxicity of the solvents used to make nanoparticles, and by the need to use transfection agents to deliver nanoparticles into c...

nanostructured zinc oxide (zno) materials have received considerable interest from scientists due to their remarkable performance in electronics, optics and photonics. zno nanoparticles were synthesized by co-precipitation method. zno nanoparticles were synthesized using zn(no3)3 and k2co3 precursors. the structure of the obtained product was confirmed by the powder x-ray diffraction (xrd) anal...