Single nucleotide polymorphisms (SNPs) of cytotoxic T lymphocyte associated antigen-4 gene (CTLA-4) have been associated with graft rejection and long-term clinical outcome after organ transplantation. Our aim was to examine the association between CTLA-4 SNPs (rs733618, rs4553808, rs5742909, rs231775, rs3087243) and long-term allograft function in Chinese renal transplant recipients. Genotypin...

Renal allograft thrombosis involving either the renal artery or the veins is a well known entity in clinical practice. This complication of the renal transplant surgery is more common in the early part of the post transplant period and it is usually associated with acute antibody mediated rejection. This more commonly occurs in the paediatric renal transplant and also seems to have some relatio...

bk virus (bkv) is a polyomavirus with seroprevalence in adults, ranging from 60 to 100%. it is considered as usual cause of renal dysfunction after the allograft renal transplantation nephropathy. potent immunosuppressive therapy in kidney transplantation can lower the rate of acute rejection. therefore, untreated bkv infections lead to kidney allograft dysfunction or loss. in order to estimate...

Acute renal failure (ARF) in the transplanted kidney represents a high-stakes area of nephrology and of transplantation practice. A correct diagnosis can lead to rapid return of renal function; an incorrect diagnosis can lead to loss of the graft and severe sequelae for the patient. The diagnostic possibilities are many (Fig. 10-1) and treatments quite different, although the clinical presentat...

This report describes a patient who developed cyclosporin-induced thrombotic microangiopathy in a renal allograft. Cyclosporin-induced thrombotic microangiopathy is considered by many as a contraindication to subsequent therapy with cyclosporin. This case is notable for successful treatment with cyclosporin following resolution of thrombotic microangiopathy in a renal allograft.

Bullous pemphigoid has been linked to allograft rejection, as well as membranous nephropathy in renal transplant recipients. Although there is a possibility of multiple distinct autoimmune processes, immune stimulation induced by allograft rejection or antibasement zone antibody interactions are possible mechanisms for the simultaneous skin and renal involvement.

Immunoperoxidase staining was carried out using monoclonal antibody against endothelin-1 on renal allograft biopsy specimens from thirty one patients with acute renal transplant rejection: Banff 97 score IA (n = 11), score IB (n = 10) and score IIA (n = 10). As a control 10 biopsy specimens of the kidneys removed because of trauma were used. Endothelin-1 immunostaining was investigated in the r...

BACKGROUND The relevance of viral infections in the development of allograft lesions is still unclear, although some viruses have been implicated. The present study investigated systemic and intrarenal viral infections in kidney transplant recipients and their association with the risk of acute rejection and chronic allograft injuries that are predictive of long-term dysfunction. METHODS The ...