Background and Purpose The epidemiological features of dermatophytoses have been characterized in many geographical locations of Iran, but not in Guilan, North of Iran. This study was carried out to determine the distribution pattern of dermatophytoses and their relevant agents in Guilan, North of Iran, over a period of one year, from April 2010 to April 2011. Materials and Methods The clinic...

Background: Xmn-1 polymorphism of 𝜸Gglobin gene (HBG2) is a prominent quantitative trait loci (QTL) in β-thalassemia intermediate (β-TI). In current study, we evaluated the frequency of Xmn-1 polymorphism and its association with β-globin gene (HBB) alleles and Hb F level in β-TI patients in Sistan and Balouchestan province, south-east of Iran. Subjects and Methods: 45 β-TI patients were enroll...

AIM To investigate if there is an association between M235T polymorphism of angiotensinogen gene and myocardial infarction (MI) risk and perform a meta-analysis and an in silico approach. METHODS This case-control study included 340 participants (155 MI patients and 185 controls) examined at Kashan University of Medical Sciences (Kashan, Iran) between 2013 and 2015. Meta-analysis included 25 ...

OBJECTIVE People are usually susceptible to carcinogenic aromatic amines, present in cigarrette smoke and polluted environment, which can cause DNA damage. Therefore, maintenance of genomic DNA integrity is a direct result of proper function of DNA repair enzymes. Polymorphic diversity could affect the function of repair enzymes and thus augment the risk of different cancers. Xeroderma pigmento...

BACKGROUND Anopheles culicifacies is a main malaria vector in southeastern part of Iran, bordring Afghanistan and Pakistan. So far, resistance to DDT, dieldrin, malathion and partial tolerance to pyrethroids has been reported in An. stephensi, but nothing confirmed on resistance status of An. culicifacies in Iran. METHODS In current study, along with WHO routine susceptibility test with DDT (...

the aim of this study was to assess the possible association between genetic polymorphisms of the glutathione s-transferase (gst) gene family and the risk of the development of metabolic syndrome (ms) in zoroastrian females in yazd, iran.in this case-control study, gstm1, t1, and p1 polymorphisms were genotyped in 51 randomly selected ms patients and 50 randomly selected healthy controls on feb...

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background: parasite lactate dehydrogenase ( p ldh) is extensively employed as malaria rapid diagnostic tests (rdts). moreover, it is a well-known drug target candidate. however, the genetic diversity of this gene might influence perfor­mance of rdt kits and its drug target candidacy. this study aimed to determine polymorphism of p ldh gene from iranian isolates of p. vivax and p. falciparum. m...

Astrocytoma as a primary tumour is the core item in this section in which, by considering a pedigree-based research approach, the involvement of Ataxia-Telangiectasia (AT) gene is investigated. The two-hit -hypothesis of Knudson’s model is given to clarify the process of tumourigenesis in retinoblastoma. Lack of any available data for any hit hypothesis in brain tumours was the reason why the t...

BACKGROUND Matrix metalloproteinases (MMPs) are upregulated in tumors. The MMP-7 A-181G polymorphism is associated with increased expression of the MMP-7 gene. Aim of the present study was to investigate the association between the MMP-7 A-181G polymorphism and susceptibility to breast cancer. PATIENTS AND METHODS The MMP-7 A-181G variants were studied in a cohort of 251 subjects consisting o...