INTRODUCTION Mastectomy is the current standard of care for ipsilateral breast tumor recurrences after prior whole breast irradiation (WBI). We report our single-institution experience with breast-conserving surgery (BCS) followed by intraoperative radiotherapy (IORT) as an alternative to salvage mastectomy for new or recurrent breast cancers that develop in the setting of prior thoracic radiat...

introduction: intraoperative radiation therapy device (iort) is one of the several options for partial breast irradiation. iort is sent to the tumor bed during surgery and can be replaced with conventional standard therapy (ebrt). the aim of this study was to evaluate the safety and effectiveness of iort machine compared with ebrt and to determine the dominant option in terms of the cost-effect...

Intraoperative radiation therapy (IORT) is a multidisciplinary approach in which residual tumors or tumor beds are directly irradiated during a surgical procedure. To evaluate its efficacy, from 1985, we conducted a prospective study including non-metastatic gastric adenocarcinoma treated by surgery, IORT (15 Grays) and postoperative external beam radiotherapy (44 Grays). Up to 1993, 51 ca...

Introduction: The received dose to the surface of tumor bed is one of the main issues in beast intraopeative radiotherapy (IORT). Totally, the administered dose to the surface is usually lower than that of radiotherapy reference point (distal end of tumor bed). Employing a buildup bolus can effectively increase the surface dose and therefore, eliminate such created cold points ...

INTRODUCTION Among the high grade cerebral gliomas, Glioblastoma multiform for instance, would be the main pattern of local recurrence causes clinical deterioration and deaths. This has observed 2 - 3 cm upon the initial lesion. During the period of 2 - 4 weeks post-surgery, remaining tumor cells have re-grown until radiochemotherapy has initiated. So it has seemed clear that improved local con...

BACKGROUND The Montpellier cancer institute phase II trial started in 2004 and evaluated the feasibility of intraoperative radiotherapy (IORT) technique given as a sole radiation treatment for patients with an excellent prognostic and very low recurrence risk. METHODS Forty-two patients were included between 2004 and 2007. Inclusion criteria were patients ≥ 65 years old, T0-T1, N0, ductal inv...

In this work, organized as a short review, we present some results obtained by applying the Monte Carlo techniques in the Intra-Operative Radiation Therapy (IORT). The electron beams generated by the NOVAC7 IORT accelerator have been simulated using BEAMnrc/EGSnrc Monte Carlo code, the dose distributions and water-to-air stopping power ratios being later calculated with the associated software ...

Background: Intraoperative radiation therapy (IORT) is a novel approach to breast cancer (BC) treatment. Objectives: In this study, we compared the cellular and molecular effects of IORT-treated post-lumpectomy wound fluid (seroma) at point IOeRT versus IOxRT on BC cell line. Methods: Immortalized human lines: MCF-7, MDA-MB-231, MCF10 were incubated with seroma from 3 groups patients (as pilot ...

Although there have been significant advances in the adjuvant therapy of colorectal cancer, results for patients have historically been poor when complete resection is unlikely or not possible. Similarly, locally recurrent colorectal cancer patients often experience significant tumor related morbidity and disease control and long term survival have historically been poor with standard therapies...