Radiotherapy has been used to treat cancer for >100 years and is required by numerous patients with cancer. Ionizing radiation effectively inhibits the growth of cancer cells by inducing cell death and increasing anticancer immunity, through the induction of natural killer group 2 membe r D ligands (NKG2DLs); however, adverse effects have also been reported, including the promotion of metastasi...

As we enter the new millennium, population explosion, increasing worldwide energy demands and rapid global increase in ionizing radiation are all now threatening our fragile environment like no other time in known history. There is an urgent need for research and education to focus on the complex and direct link between ionizing radiation and its irreversible impact on the environment. Hence, n...

Previous studies have demonstrated that ionizing radiation induces the expression of certain cytokines, such as TNF alpha/cachectin. However, there is presently no available information regarding the molecular mechanisms responsible for the regulation of cytokine gene expression by ionizing radiation. In this report, we describe the regulation of the TNF gene by ionizing radiation in human myel...

We examined associations between low-level exposure to ionizing radiation and mortality among 14,095 workers hired at the Oak Ridge National Laboratory between 1943 and 1972. Workers at the facility were individually monitored for external exposure to ionizing radiation and have been followed through 1990 to ascertain cause of death information. Positive associations were observed between low-l...

RAD51 has critical roles in homologous recombination (HR) repair of DNA double-strand breaks (DSB) and restarting stalled or collapsed replication forks. In yeast, Rad51 function is facilitated by Rad52 and other "mediators." Mammalian cells express RAD52, but BRCA2 may have supplanted RAD52 in mediating RAD51 loading onto ssDNA. BCCIP interacts with BRCA2, and both proteins are important for R...

Polyphenol compounds were extracted from Myrtus communis L. berries (Myrtaceae) by maceration in 70% ethanol and analysed by HPLC-DAD and electrospray mass spectrometry. The Myrtus berries were collected at maturity from seven localities on the island of Corsica (France) and the sampling was carried out during three years. The polyphenol composition of Corsican Myrtus berries was characterized ...

Deinococcus radiodurans is among a small number of bacterial species that are extremely resistant to ionizing radiation, UV light, toxic chemicals, and desiccation. We measured proteome oxidation (i.e., protein carbonylation, PC) in D. radiodurans as well as in standard and evolved resistant strains of Escherichia coli exposed to ionizing radiation or UVC light and found a consistent correlatio...

Physics is the science that studies the interaction between matter and energy. This discipline studies the general properties of bodies, the forces that modify the transfer of energy and the interaction between particles. Physics now has many branches, and one of them is the Biomedical Physics. Biomedical Physics in Medicine applies the principles and methods of physics. This will generate new ...

introduction: nowadays ionizing radiation has a considerable contribution in medical diagnostic and treatment. using ionizing radiation is increasing rapidly, so biological effects of ionizing radiation should be considered more. x-rays in the range of diagnostic radiology have hazardous effects and risks that are defined as random effects. these effects obey the lnt hypothesis that occur at lo...

BACKGROUND Efficient stem cell differentiation is considered to be the holy grail of regenerative medicine. Pursuing the most productive method of directed differentiation has been the subject of numerous studies, resulting in the development of many effective protocols. However, the necessity for further improvement in differentiation efficiency remains. This review contains a description of m...