Background: The aim of this study is to formulate nanosuspension Scoparia dulcis. This plant species mainly used as an analgesic, antipyretic, and urinary issues well stomach disorders, kidney stones, hypertension, diabetes, inflammation. In alcoholic extracts dulcis are used. ionic gelation method the most suitable polyherbal nanosuspension. Methods: Herbal was prepared by emulsion method. Chi...

Improving oral bioavailability of drugs given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. To address this encumbrance, ionotropic gelation technique has attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by engineering spherical agglomerates. Spherical beads...

We have studied a series of samples of bovine serum albumin (BSA) solutions with protein concentration, c, ranging from 2 to 500 mg/mL and ionic strength, I, from 0 to 2 M by small-angle X-ray scattering (SAXS). The scattering intensity distribution was compared to simulations using an oblate ellipsoid form factor with radii of 17 x 42 x 42 A, combined with either a screened Coulomb, repulsive ...

Objective: This research was conducted to determine inhibition activity of curcumin nanoparticles against α-amylase and α-glucosidase enzymes.
 Methods: Curcumin nanoparticle made by ionic gelation method using chitosan as cation, sodium tripolyphosphate polyanion, tween 80 surfactant. were tested for inhibitory enzymes UV-Vis spectrophotometry at λ= 595 nm 305 nm, respectively.
 Resu...

The cold gelation of preheated whey protein isolate (WPI) solutions at alkaline conditions (pH>10) has been studied to better understand the effect of NaOH in the formation and destruction of whey protein aggregates and gels. Oscillatory rheology has been used to follow the gelation process, resulting in novel and different gelation profiles with the gelation pH. At low alkaline pH, typical sol...

Biopolymeric nanoparticles were synthesized using Gellan Gum and loaded with Atenolol, an antihypertensive drug by ionotropic gelation (an easy ecofriendly system) induced BaCl2 as ionic crosslinking agent to improve absorption bioavailability of drug. These characterized scanning electron microscope, fourier-transform infrared spectroscopy, X-ray diffraction analysis dynamic light scattering t...

Abstract – HCTN7. Plasma cholesterol level plays an important role in atherosclerosis and cardiovascular diseases. Piperine, alkaloid form of black pepper is known to reduce uptake. In this paper, piperine-loaded chitosan nanoparticles (CTS-PIP NPs) were prepared by ionic gelation method. Molecular interactions among the components confirmed FT-IR spectroscopy. Transmission electron microscopy ...

This review compiles information regarding the use of alginate, and in particular alginate hydrogels, in culturing cells in 3D. Knowledge of alginate chemical structure and functionality are shown to be important parameters in design of alginate-based matrices for cell culture. Gel elasticity as well as hydrogel stability can be impacted by the type of alginate used, its concentration, the choi...

Objective: The objective of this study was to formulate an oral sustained release delivery system of ezetimibe mucoadhesive beads by ionic gelation technique based on sodium alginate used as a hydrophilic carrier in combination with carbopol 934P which acts as a rate modifier. Methods: Microbeads of ezetimibe were prepared using an easy method of ionotropic gelation by little modification while...

By William A. Eaton and James Hofrichter T HE FUNDAMENTAL cause ofsickle cell disease is the decreased deformability of the sickled red cell produced by gelation of hemoglobin S. Partial inhibition of gelation should therefore reduce clinical severity, while complete inhibition should result in a “cure.” These basic ideas have stimulated an enormous effort to understand the gelation process in ...