ion for Data Validation and Therapy Planning for Artificially Ventilated Newborn Infants”, Artificial Intelligence in Medicine, 8(6),

Test measurements with 241Am-α-particles, 12C, 20Ne, 58Ni, 208Pb and 238U projectiles are performed. It is shown that the most important charactristics of heavy-ion diamond detectors are described by the shaping parameters of the detectors single pulse. Distributions of rise and decay times of the signals as well as of the associated charge amplitudes are discussed. An intrinsic time resolution...

Heavy charged particles interact with matter predominantly through inelastic collisions with atomic electrons. Slower particles give more energy to the electrons in comparison with faster particles; therefore, the delivered dose increases while the particle energy decreases. The point at which the particles deposit most of their energy is called the Bragg peak. The presence of a Bragg peak make...

Treatment planning for ion therapy requires precise knowledge about the biological effectiveness of particle beams, which is strongly determined by the microscopic radial energy deposition around individual ion tracks. Therefore, we applied the Local Effect Model (LEM) to investigate the dependence of the relative biological effectiveness (RBE) on different representations of the radial dose di...

Cancer therapy with light heavy ions is now a well proven technology. Almost all facilities are running Electron Cyclotron Resonance Ion Sources (ECRIS) to produce carbon ions and protons as well. In the 1990’s the idea of using a Electron Beam Ion Source (EBIS) was proposed [1]. Some proof of principle measurements were carried out [2] but the application of EBIS ion sources in radiation facil...

The aim of this study was to prospectively assess 5-year health-related quality of life (HRQOL) of patients treated with carbon ion radiotherapy (C-ion RT) for clinically localized prostate cancer. A total of 417 patients received carbon ion radiotherapy at a total dose of 63-66 Gray-equivalents (GyE) in 20 fractions over 5 weeks, and neoadjuvant and adjuvant androgen deprivation therapy (ADT) ...

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.