IN 1944, Morton et al. observed that when 300 mg. of sheep thyroid slices were incubated in 3 cc. of a bicarbonate-Ringer medium to which various amounts of I as inorganic iodide had been added, inhibition of thyroxine and diiodotryosine formation occurred when the added I exceeded 20 gamma. The resemblance of this in vitro effect to the action of excess iodide in Graves' disease in man led us ...

BACKGROUND Placental transport of iodide is required for fetal thyroid hormone production. The sodium iodide symporter (NIS) mediates active iodide transport into the thyroid and the lactating mammary gland and is also present in placenta. NIS is competitively inhibited by thiocyanate from maternal smoking, but compensatory autoregulation of iodide transport differs between organs. The extent o...

The global effort to prevent iodine deficiency disorders through iodine supplementation, such as universal salt iodization, has achieved impressive progress during the last few decades. However, iodine excess, due to extensive environmental iodine exposure in addition to poor monitoring, is currently a more frequent occurrence than iodine deficiency. Iodine excess is a precipitating environment...

129I is a major by-product of nuclear fission that is of concern because of its extremely long half-life (~16 million yrs), perceived toxicity through bioaccumulation, and the increasing inventory of this radionuclide worldwide. Relatively high concentrations of iodate (27.3%) and organoiodine (23.9%) are present in a 129I-conatminated aquifer at the Savannah River Site (SRS), SC, U.S.A. To det...

Precious metals are the most attractive resources in waste printed circuit boards (PCBs) of mobile phones. In this work, an alternative process for recovering Au, Ag, and Pd from waste PCBs of mobile phones by supercritical water oxidation (SCWO) pre-treatment combined with iodine-iodide leaching process was developed. In the process, the waste PCBs of mobile phones were pre-treated in supercri...

background & objectives: iodine deficiency disorder (idd) is the most common endocrine disorder in the world. it is estimated that about 1.5 billion people are in iodine deficiency state. many studies have shown the high prevalence of endemic goiter and iodine deficiency in iran.  for control of this health problem salt iodinization is the best  accepted strategy in the world. the main objectiv...

High-resolution Magnetic Resonance Imaging (MRI) has been the primary modality for obtaining 3D cross-sectional anatomical information in animals for soft tissue, particularly brain. However, costs associated with MRI can be considerably high for large phenotypic screens for gross differences in the structure of the brain due to pathology and/or experimental manipulations. MicroCT (mCT), especi...

Herein we report a new method for synthesizing stabilized magnetic nanoparticle (MNP) colloids. A new class of monodisperse water-soluble magnetite nano-particles was prepared by a simple and inexpensive co-precipitation method. Iron ions and iodine were prepared by the reaction between ferric chloride and potassium iodide. The ferrous and ferric ions were hydrolyzed at low temperature at pH 9 ...

Chernobyl demonstrated that iodine-131 (131I) released in a nuclear accident can cause malignant thyroid nodules to develop in children within a 300 mile radius of the incident. Timely potassium iodide (KI) administration can prevent the development of thyroid cancer and the American Thyroid Association (ATA) and a number of United States governmental agencies recommend KI prophylaxis. Current ...

Iodide retards or prevents hypercholesterolemia and the development of experimental atherosclerosis in rabbits. "Prote(ction" is estimated from reduction of plasma and/or hepatic cholesterol. Small doses of iodide do not "protect." Iodide in large doses prevents the hypercholesterolemia resulting from exogenous cholesterol and reduces hepatic cholesterol. This effect is independent of the thyro...