The one- or two-electron oxidation of thyroglobulin by the thyroid peroxidase system was found to be regulated by the iodine content of thyroglobulin. The catalytic intermediate of thyroid peroxidase observed at steady state of the reaction was Compound I and II when the iodine content in thyroglobulin was 0.2 and 0.7%, respectively, apparent rate constants for the rate-limiting steps being est...

As a tool with which to detect iodinated compounds in human thyroid specimens, we have reevaluated a nonincineration technique which has so far been employed in the determination of thyroxine-iodine in peripheral blood. The catalytic action of iodoamino acids in the Ce-As reaction was enhanced by a small amount of Cl2. On the contrary, a large amount of Cl2 inhibited the reaction unexpectedly. ...

Thyroglobulin was isolated from thyroid glands of normal guinea pigs and from animals treated with thiouracil. These preparations were fractionated by isopyknic centrifugation in RbCl into proteins of varying iodine content. When the disulfide bonds of these protein fractions were reduced and analyzed by polyacrylamide gel electrophoresis in Na dodecyl-SO4, t hree species were observed with mol...

Coal combustion is the primary anthropogenic source of atmospheric iodine, which has important environmental and health effects. The iodine distribution in Chinese coals and the atmospheric iodine emission factors of coal-fired boilers are studied to estimate the iodine atmospheric flux from coal combustion in China from 1995 to 2009. The national average iodine content weighted by coal yield f...

In order to start a goitre prevention program in Shahriar area, a survey of the disease prevalence and possible contributory factors was conducted. Three hundred and sixty seven households chosen randomly, were surveyed as to their economic, sociocultural and goitre status. Urinary excretion of iodine and iodine content of water in the area was measured. Food consumption survey demonstrated tha...

OBJECTIVE To evaluate the effectiveness of universal salt iodization (USI) for the control of IDD in Hebei province since it was implemented in 1995, identify the problems currently encountered in the implementation of USI and provide practical proposals for addressing these problems. METHODS Probability proportionate to size sampling (PPS) was employed in the surveillance of IDD, for which a...

Current methods for assessment of iodine intake in a population comprise measurements of urinary iodine concentration (UIC), thyroid volume by ultrasound (US-Tvol), and newborn TSH. Serum or dried blood spot thyroglobulin (DBS-Tg) is a new promising functional iodine status biomarker in children. In 1996, a new act on universal salt iodination was introduced in Croatia with 25 mg of potassium i...