Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that causes frequent hematological disorders. Thrombocytopenia can occur in 30% of patients with SLE according to some series [1]. Typically, such alterations are controlled with classical immunosuppressants such as oral steroids, hydroxychloroquine, azathioprine and others. In some cases requires the use of more aggressive int...

OBJECTIVE To observe the clinical characteristics of patients with Kawasaki disease whose parent also had the same disorder. DESIGN Cross-sectional study using the data from nationwide surveys of Kawasaki disease in Japan. SETTING All hospitals with a bed capacity of 100 or more and pediatric departments in Japan. PATIENTS All patients described on the 16th and 17th surveys covering the 4...

INTRODUCTION Infant botulism is a rare, probably underdiagnosed, life-threatening disease caused by the toxin-producing bacterium Clostridium botulinum. METHODS We investigated reported cases of infant botulism in Denmark from 1995 to 2015, and compared the incidence with that of other western countries. RESULTS We found nine cases of infant botulism in Denmark from 1995 to 2015. The incide...

Therapeutic preparations of polyspecific IgG obtained from plasma pools of a large number of normal donors (IVIg) express anti-idiotypic activity against a wide spectrum of natural and disease-associated autoantibodies. The present study investigated the origin of anti-idiotypic activity against autoantibodies to factor VIII. The neutralizing activity of pools of IgG against patients' anti-fact...

It is generally agreed that y globulin concentration in spinal fluid is elevated in some 60% of cases of multiple sclerosis (Kabat, Freedman, Murray, and Knaub, 1950; Roboz, Hess, and Forster, 1953; Yahr, Goldensohn, and Kabat, 1954; Ivers, McKenzie, McGuckin, and Goldstein, 1961; Schapira and Park, 1961; Foster and Horn, 1962). Whilst little is known of its origin or direct pathological signif...

The prediction of antibody-protein (antigen) interactions is very difficult due to the huge variability that characterizes the structure of the antibodies. The region of the antigen bound to the antibodies is called epitope. Experimental data indicate that many antibodies react with a panel of distinct epitopes (positive reaction). The Challenge 1 of DREAM5 aims at understanding whether there e...

INTRODUCTION G enitourinary tuberculosis (GUTB) is an uncommon form of tuberculosis, and its prevalence has shown a declining trend. Tuberculous ureteral involvement is a serious problem with possible grave consequence if not detected and treated timely. Therefore, frequent intravenous urographies (IVU) are recommended both during the initial phase when anti-tuberculous treatment (ATT) is start...

The aim of this study is to assess the actual epidemiologic features of Kawasaki disease (KD) in Korea using the data from Health Insurance Review & Assessment Service (HIRA) claims from 2007 to 2014. We investigated HIRA claims of patients who had KD (International Classification of Diseases-10, M30.3) as a major diagnosis and were given intravenous immunoglobulin (IVIG) from 2007 to 2014. A t...