STUDY OBJECTIVE The 2 antidotes for acute cyanide poisoning in the United States must be administered by intravenous injection. In the out-of-hospital setting, intravenous injection is not practical, particularly for mass casualties, and intramuscular injection would be preferred. The purpose of this study is to determine whether sodium nitrite and sodium thiosulfate are effective cyanide antid...

Introduction Many intravenous (IV) drugs are required for complex and polypathologic critically ill ICU patients management. ICU nurses are daily confronted with drugs preparation and administration (solvent type and volume, infusion rate). They also have to deal with drugs physiochemical incompatibilities (PCI), especially as various IV medications are delivered via a single catheter lumen. PC...

OBJECTIVES To determine the incidence and clinical importance of errors in the preparation and administration of intravenous drugs and the stages of the process in which errors occur. DESIGN Prospective ethnographic study using disguised observation. PARTICIPANTS Nurses who prepared and administered intravenous drugs. SETTING 10 wards in a teaching and non-teaching hospital in the United ...

background : propylene glycol (1,2-propanediol, pg) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. while pg is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. objective: to evaluate the effect of pg in sepsis induced by the bacterial endotoxin lipopolysaccharide (lp...

The treatment of advanced colorectal cancer over the past 4 decades has required the use of intravenous chemotherapy, most typically fluorouracil (5-FU). The possibility of providing an alternative to intravenous delivery while at the same time improving the quality of life of patients who require fluorouracil for advanced or adjuvant therapy has provided the stimulus for the development of ora...

The chick embryo chorioallantoic membrane (CAM) is a preclinical model widely used for vascular and anti-vascular effects of therapeutic agents in vivo. In this study, we examine the suitability of CAM as a predictive model for acute toxicology studies of drugs by comparing it to conventional mouse and rat models for 10 FDA-approved anticancer drugs (paclitaxel, carmustine, camptothecin, cyclop...

The hospital is a health facility that provides diagnostic and therapeutic services to patients for various diseases mental problems, both surgical non-surgical. It place get healing an illness suffered. At present medical devices need attention the right results when treating patients, of course, increasing technological sophistication. One common procedures performed on administer drugs via i...

T he Cardiovascular and Renal Advisory Panel of the FDA met January 27-28, 1998, to discuss (1) evaluation and use of intravenous inotropic agents in patients with heart failure; (2) liver function test abnormalities with a new AT 1 receptor blocker, tasosartan; and (3) the use of the platelet IIb/IIIa receptor blocker eptifibatide in syndromes of acute cardiac ischemia. Intravenous drugs for t...

A nulliparous non-descript mare presented at full term with a history of straining (utero-abdominal contractions) for the last 24 hours. Vaginal examination revealed dead foal in posterior presentation bilateral hip flexion and dorso-iliac left position. Pre-operatively, 5 mL Tetanus toxoid as intramuscular injection, 3g Ceftriaxone 4 Dexamethasone 3L 5% Dextrose normal saline (DNS) intravenous...