Spinally transected rats given leg shock whenever one hindlimb is extended learn to maintain the leg in a flexed position, which minimizes net shock exposure. Yoked rats, that receive an equal amount of shock independent of leg position (noncontingent shock), do not exhibit an increase in flexion duration. Yoked rats also fail to learn when response contingent shock is applied to the previously...

I read with a great interest the recent article by Alebouyeh et al. about intrathecal administration of amitriptyline and doxepin to induce spinal blockade and comparison of their effects with those of bupivacaine (1). Alebouyeh et al. reported that intrathecal injection of various drugs with different mechanisms is an intriguing issue in anesthesiology and pain management. Antidepressants are ...

Ropivacaine test dose in extradural anaesthesia Morton and colleagues 1 have described the use of 0.75% ropiva-caine for extradural anaesthesia, and in the process have clearly demonstrated the unsuitability of this agent as a test dose. The aim of an extradural test dose is to identify inadvertent i.v. or intrathecal catheter placement. It should have high sensitivity, but produce symptoms tha...

conclusions the addition of 50 mg of magnesium sulfate to a bupivacaine–fentanyl solution for intrathecal anesthesia improved the efficacy and duration of the analgesia without any significant side effects. the addition of 150 µg of neostigmine increased the incidence of hypotension, bradycardia, and nausea and vomiting. moreover, neostigmine failed to prolong analgesia duration. results group ...

The concept that a barrier exists between the blood and the brain was first formulated nearly a century ago. Colored dyes injected into the circulation of laboratory animals stained all tissues except the brain. However, when the same dyes were introduced into cerebral spinal fluid (CSF), the liquid that bathes, nourishes, and cushions the brain and spinal cord, brain cells were readily stained...

Abstract Objective To systematically review the evidence for intrathecal or intraventricular plus intravenous administration of antibiotics compared with standard management postsurgical meningitis ventriculitis. Methods The following databases were searched: MEDLINE, Central Register Controlled Trials (CENTRAL); PubMed, EMBASE; and reference list articles. Results Administration intrathecal/in...

intrathecal injection of sufentanil with adrenalin was performed in 45 cases (20 female, 25 male age range: 18-40 years). all injections were performed in the sitting position, with a number 20 intrathecal needle immersed in adrenalin. the cases were observed for 72 hours. maximum duration of analgesia was 12 hours (60%) and the minimum was 3 hours (13.3%). this method reduces the need for repe...