Spinal anaesthesia for Caesarean section is associated with an unacceptably high incidence of hypotension despite the administration of an intravenous fluid preload and the use of uterine displacement. The theoretical benefits of preventing hypotension as opposed to treating it as it occurs are the avoidance o f considerable maternal discomfort, a reduced risk o f serious cardiovascular or resp...

background and aim: the third stage of labour is one of the most troublesome stages of child delivery. the basic principle of the third stage management is administrating prophylactic uterotonics. however, the time of its administration varies in different hospitals. this study aimed to determine the effect of intramuscular oxytocin injection after emergence of the fetal anterior shoulder or pl...

We have recently demonstrated that adeno-associated virus serotype 9 (AAV9)-mediated human erythropoietin (hEPO) gene delivery into the brain protects dopaminergic (DA) neurons in the substantia nigra in a rat model of Parkinson's disease. In the present study, we examined whether pre-exposure to AAV9-hEPO vectors with an intramuscular or intrastriatal injection would reduce AAV9-mediated hEPO ...

The administration of intramuscular injections is a common nursing intervention in clinical practice. This article aims to raise awareness of the use of the ventrogluteal site for administering intramuscular injections. It describes the main reasons for using this site and outlines the complications associated with the dorsogluteal site. It is hoped that this review of the literature will shift...

1. Intramuscular dosage of antipneumococcus sera in a standard dermal pneumococcic infection in rabbits is as effective as intravenous dosage provided the degree of blood stream invasion be not unusually high. 2. The immediate bactericidal effect of doses of serum given intramuscularly is equal to that of the same doses given intravenously in the cases of mild and moderately severe bacteremias....

The rapid corticotropin test with synthetic corticotropin ( 1-24 peptide) was studied. A single intravenous injection of the corticotropin was performed in 26 human subjects. The increment of plasma 11-0HCS concentration by the administration was less than that of NH-corticotropin dripping infusion or synthetic corticotropin intramuscular injection. Intramuscular rapid corticotropin test was co...

Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal al...

Adults with malaria in Sri Lanka were treated with parenteral chloroquine diphosphate, either 2.5 mg base/kg intramuscularly at 0, 1, 12, 13, 24, and 25 hours or 5 mg base/kg subcutaneously at 0, 12, and 24 hours. Both regimens were completed with oral chloroquine phosphate, 5 mg base/kg, at 36 and 48 hours. Mean peak chloroquine concentrations in the first 12 hours, which were 0.5 (range 0.3-0...

Recently, a study on 5 patients [Holbrook et al.: J Allergy Clin Immunol 2013;132:1219-1220] documented the efficacy of the intravenous administration of ondansetron in children with acute symptoms due to food protein-induced enterocolitis syndrome (FPIES). We report on the experience at our institution using ondansetron during oral food challenge (OFC) in 5 children affected by FPIES. In all 5...

Intradermal administration of recombinant interferon gamma (rIFN-gamma) to lepromatous leprosy patients has converted the local histology toward a tuberculoid pattern. However, such changes have been confined to the site of injection. In contrast, in the present study, marked, intradermal accumulation of CD3+, CD4+, CD8+, and CD1a+ T cells and Leu-M5+ mononuclear phagocytes was induced at a dis...