نتایج جستجو برای: intramolecular michael addition

تعداد نتایج: 747019  

Journal: :Organic & biomolecular chemistry 2012
Ke Chen Sumod A Pullarkat

A palladacycle-catalyzed tandem Heck-intramolecular aza-Michael reaction protocol has been developed for the one-pot synthesis of 1-substituted isoindolines from N-unprotected 2-bromobenzylamines and acrylates with high yields.

Journal: :Organic & biomolecular chemistry 2014
Philipp Fruhmann Theresa Weigl-Pollack Hannes Mikula Gerlinde Wiesenberger Gerhard Adam Elisabeth Varga Franz Berthiller Rudolf Krska Christian Hametner Johannes Fröhlich

Methylthiodeoxynivalenol (MTD), a novel derivative of the trichothecene mycotoxin deoxynivalenol (DON), was prepared by applying a reliable procedure for the formal Michael addition of methanethiol to the conjugated double bond of DON. Structure elucidation revealed the preferred formation of the hemiketal form of MTD by intramolecular cyclisation between C8 and C15. Computational investigation...

Journal: :Organic letters 2015
Xiang-Wei Du Levi M Stanley

Tandem reactions involving Rh-catalyzed intermolecular hydroacylations of alkynes with salicylaldehydes followed by intramolecular oxo-Michael additions are described for the diastereoselective synthesis of 2,3-disubstituted chroman-4-ones. The tandem hydroacylation/oxo-Michael additions occur to form 2,3-disubstituted chroman-4-ones in high yields from a range of 1,2-disubstituted acetylenes a...

2015
Yusuke Kobayashi Ryuta Kuramoto Yoshiji Takemoto

The first catalytic asymmetric synthesis of the key intermediate for beraprost has been achieved through an enantioselective intramolecular oxa-Michael reaction of an α,β-unsaturated amide mediated by a newly developed benzothiadiazine catalyst. The Weinreb amide moiety and bromo substituent of the Michael adduct were utilized for the C-C bond formations to construct the scaffold. All four cont...

Journal: :Physical chemistry chemical physics : PCCP 2015
Michael H Abraham Raymond J Abraham Abil E Aliev Claudio F Tormena

Correction for 'Is there an intramolecular hydrogen bond in 2-halophenols? A theoretical and spectroscopic investigation' by Michael H. Abraham et al., Phys. Chem. Chem. Phys., 2015, DOI: 10.1039/c5cp04061b.

Journal: :Angewandte Chemie 2012
Araceli G Campaña Armando Carlone Kai Chen David T F Dryden David A Leigh Urszula Lewandowska Kathleen M Mullen

Kinesin, dynein, and some myosin motor proteins transport cargoes within the cell by “walking” along polymeric filaments, that is carrying out successive, repetitive, mostly directional changes of their point of contact with the molecular track without completely detaching from it. These extraordinary biomolecules are inspiring scientists to mimic aspects of their dynamics to create artificial ...

Macchindra Tambe Somnath Gholap, Umesh Deshmukh

An efficient synthesis of some novel coumarin derivatives via 1, 4- Michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (CSA) under solvent free conditions is described. The corresponding Michael addition products were obtained in good to excellent yield. The synthesized compounds were screened for their antibacterial activity against E. coli, S. aureus and an...

Macchindra Tambe Somnath Gholap, Umesh Deshmukh

An efficient synthesis of some novel coumarin derivatives via 1, 4- Michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (CSA) under solvent free conditions is described. The corresponding Michael addition products were obtained in good to excellent yield. The synthesized compounds were screened for their antibacterial activity against E. coli, S. aureus and an...

Journal: :Journal of flow chemistry 2012
Farman Ullah Qin Zang Salim Javed Aihua Zhou Christopher A Knudtson Danse Bi Paul R Hanson Michael G Organ

A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of functionalized 1,2,5-thiadiazepane 1,1-dioxide library, utilizing a one-pot elimination and inter-/intramolecular double aza-Michael addition strategy is reported. The optimized protocol in MACOS was utilized for scale-out and further extended for library production using a multicapillary flow reactor....

Journal: :Organic & biomolecular chemistry 2004
Shoko Yamazaki Satoshi Morikawa Yuko Iwata Machiko Yamamoto Kaori Kuramoto

A novel cyclization reaction of ethenetricarboxylate derivative aromatic compounds in the presence of various Lewis acids gave benzo-annulated cyclic compounds such as oxindole and benzofuran derivatives via Friedel-Crafts intramolecular Michael addition in high yields. For example, the reaction of diethyl 2-[(N-methyl-N-phenylcarbamoyl)methylene]malonate (1a) in the presence of ZnCl2 at room t...

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