The occurrence of Crohn's disease has been studied in a population of approximately 300,000 in Blackpool, a seaside town in the north of England, and the surrounding area. Between 1968 and 1980, 156 patients resident in the area were diagnosed as having Crohn's disease - an annual incidence of 4 per 10(5). For the years 1971-75, the incidence was 3.3 per 10(5) and for 1976-80 it was 6.1 per 10(...

Secretory immunoglobulin A (SIgA) is one important line of defense in the intestinal mucosal surface to protect the intestinal epithelium from enteric toxins and pathogenic microorganisms. Multiple factors, such as intestinal microbiota, intestinal cytokines, and nutrients are highly involved in production of SIgA in the intestine. Recently, glutamine has been shown to affect intestinal SIgA pr...

Intestinal microbes shape the course of diseases such as Crohn’s disease, type 1 diabetes and multiple sclerosis — could even help to keep them in check.

Specific members of the intestinal microbiota dramatically affect inflammatory bowel disease (IBD) in mice. In humans, however, identifying bacteria that preferentially affect disease susceptibility and severity remains a major challenge. Here, we used flow-cytometry-based bacterial cell sorting and 16S sequencing to characterize taxa-specific coating of the intestinal microbiota with immunoglo...

Crohn's disease is a chronic inflammatory condition most commonly affecting the ileum and colon. The aetiology of Crohn's disease is complex and may include defects in peptidoglycan recognition, and/or failures in the establishment of intestinal tolerance. We have recently described a novel constitutive endogenous delivery system for the translocation of nanomineral-antigen-peptidoglycan (NAP) ...

AIM To identify definitions of cytomegalovirus (CMV) infection and intestinal disease, in inflammatory bowel disease (IBD), to determine the prevalence associated with these definitions. METHODS We conducted a systematic review and interrogated PubMed, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings ...

BACKGROUND Untreated celiac disease has traditionally been linked to a greater risk for small intestinal bacterial overgrowth, but the existing evidence is inconclusive. AIMS To compare the prevalence of small intestinal bacterial overgrowth in subjects with celiac disease compared with control subjects and patients with irritable bowel syndrome. MATERIAL AND METHODS The study included 15 u...

were registered citizens of Stockholm County at the time of definite diagnosis. These patients were followed up and investigated with reference to the occurrence of and outcome after treatment for anal fistulae. These fistulae were recorded in 184 patients (23 %/.). The incidence of anal fistulae increased the further distally the intestinal lesion was located. Healing followed local operation ...

conclusions in this study, high prevalence of 91.7% hcmv gb1 genotype was predominant among hcmv-positive uc patients, which suggests that there might be an association between hcmv gb genotype 1 and uc disease. results among 98 patients with uc, only 12 (12.2%) patients were positive for hcmv genome, while the hcmv genome was not detected in any of the controls. (p = 0.002). the distribution o...

Granulomatous colitis is a chronic transmural disease of unknown etiology gastro-intestinal tract. It can affect any area the GI In recent decades, there has been an increase in number cases disease, which be explained by improvement diagnostic methods on one hand, and deterioration environmental factors other hand. The main intestinal complications granulomatous are: obstruction, perforation, ...