The unconjugated bile salt, sodium deoxycholate, at a concentration of 0.5 mM was shown to inhibit the intestinal uptake of the amino acids L-glycine, L-leucine, L-proline, L-lysine and L-tyrosine in rats in vitro. This effect was acutely reversible except for the basis amino acid L-lysine and is therefore not simply due to tissue damage. These results, and the recent finding that sodium deoxyc...

Spontaneous bacterial peritonitis is a common illness in patients with cirrhosis and ascites that occurs without any apparent focus of infection. Bacterial translocation plays an important role in spontaneous bacterial peritonitis and it is evident from a variety of studies that the gut is a major source of this bacteria. Gut motility alterations, along with bacterial overgrowth and changes in ...

background: to estimate the prevalence of small intestine bacterial overgrowth (sibo) among patients with irritable bowel syndrome (ibs) versus healthy subjects with the use of a glucose breath test (gbt) in our geographical area. materials and methods: this study included a total of 80 consecutive patients; 40 with ibs based on rome iii criteria and 40 healthy controls with similar age and sex...

INTRODUCTION Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by symptoms, such as abdominal pain, bloating, diarrhea, and constipation, that are not attributable to structural or biochemical abnormalities (1). Although several conceptual models of IBS pathogenesis have been suggested, including visceral hypersensitivity, abnormal intestinal motility, ...

Alcoholic liver disease is a leading cause of morbidity and liver-related death worldwide. Intestinal bacterial overgrowth and dysbiosis induced by ethanol ingestion play an important role in the pathogenesis of alcoholic liver disease. After exposure to alcohol in the lumen, enteric bacteria alter their metabolism and thereby disturb intestinal homeostasis. Disruption of the mucosal barrier re...