The objective of this study was to assess the feasibility and reliability of using miniaturized disk dissolution apparatus for intrinsic dissolution rate (IDR) measurement in the early drug discovery process when bulk drug supply is very limited. The two apparatus, a miniaturized rotating disk system (mRDS) and a miniaturized stationary disk system (mSDS), were evaluated using chloramphenicol a...

INTRODUCTION Previous studies showed that aggression is an important reason to prescribe as-needed medication. The objective of this study was to compare the use of as-needed medication in aggressive and non-aggressive psychiatric patients and to explore patterns of administration of as-needed medication around aggressive incidents. METHODS An observational study in three psychiatric wards wa...

The inflammatory response is a critical molecular defense mechanism of the innate immune system that mediates the elimination of disease-causing bacteria. Repair of the damaged tissue, and the reestablishment of homeostasis, must be accomplished after elimination of the pathogen. The innate defense regulators (IDRs) are short cationic peptides that mimic natural host defense peptides and are ef...

Consistency analysis (IDR analysis) has been used to process ENCODE and modENCODE production dataset. This is a non-technical introduction on the statistical method of the consistency analysis (a.k.a. IDR analysis). It describes the consistency analysis on a pair of replicates.

Assessing the structural capacity of an irregular structure requires appropriate and robust representation analytical model. Conventional procedures are flawed because they lack reversal effects higher modes. Therefore, more have been tested to accurately capture building-type structures. Some these may be classified as adaptive pushover techniques in which lateral load vector is revised instan...

This paper proposes a new semi-active variable stiffness and damping system (AVSD) for vibration control of civil engineering structures. The AVSD system can alter rigidity and damping of the controlled structure at each control interval to attenuate the structural responses. The composition of two hydraulic cylinder-piston systems of the AVSD system is capable of amplifying the interstory drif...

Tuberculosis is an ongoing threat to global health, especially with the emergence of multi drug-resistant (MDR) and extremely drug-resistant strains that are motivating the search for new treatment strategies. One potential strategy is immunotherapy using Innate Defence Regulator (IDR) peptides that selectively modulate innate immunity, enhancing chemokine induction and cell recruitment while s...

Nowadays, the construction of a Geographical Information System on a commercial package takes up a great deal of time and resources. However, the distribution of such an application can be more expensive than the construction because of the need to distribute the commercial package with the application. Usually, commercial packages cover this lack by providing reduced versions from their powerf...