Background: A patient with multiple myeloma developed myelodysplastic syndrome (MDS). Chromosomal analysis performed after the development of MDS revealed monosomy of chromosome 9 in all the meta-phases. We wished to identify the extent of the clone with the chromosomal abnormality originating from MDS clone. Methods: A correlative interphase study by fluorescence in situ hybridization (FISH) w...

INTRODUCTION The limitation of cytogenetic analysis is that the Ph chromosome cannot be detected in clumped metaphase or in interphase cells. Fluorescence in situ hybridization (FISH) is a highly sensitive molecular genetic technique, which enables to detect break point cluster region--Abelson (BCR-ABL) complex and minimal residual disease in all Ph positive CML patients not only in metaphase b...

We present a modeling and computational approach to study fusion of multicellular aggregates during tissue and organ fabrication, which forms the foundation for the scaffold-less biofabrication of tissues and organs known as bioprinting. It is known as the phase field method, where multicellular aggregates are modeled as mixtures of multiphase complex fluids whose phase mixing or separation is ...

We report here several experiences of interphase cytogenetics, using fluorescence in situ hybridization (FISH) technique, for the detection of chromosome aberrations. FISH, using alpha satellite specific probes of 18, X, Y chromosomes, was done in interphase nuclei from peripheral blood of patients with Edwards' syndrome, Klinefelter's syndrome and Turner's syndrome with healthy male and female...

background : the word death has been brought in several verses of quran. the purpose of this study is to discuss and compare similarities and differences between quran’s and forensics’ perspective in terms of death. methods: the present study is carried out by library studies on multiple interpretations of quran, interpretation of juridical references and comparing them with current forensics k...

In order to facilitate improved returns to research and development in African agriculture, the innovation systems approach which engenders the involvement of multiple stakeholders in its innovation pathway, has been proposed. Despite the potential of this approach, the understanding of its implementation and particularly of the process of setting up its multi-stakeholder platform is still larg...

Pericentriolar material (PCM) mediates the microtubule (MT) nucleation and anchoring activity of centrosomes. A scaffold organized by Centrosomin (Cnn) serves to ensure proper PCM architecture and functional changes in centrosome activity with each cell cycle. Here, we investigate the mechanisms that spatially restrict and temporally coordinate centrosome scaffold formation. Focusing on the mit...

A fiber’s efficiency in a short-fiber composite can be accurately solved by shear-lag methods, which can account for fiber geometry, an imperfect interface (or interphase), and extend to low volume fractions. Such an analysis was used to evaluate the aspect ratio requirements for singlewalled nanotubes (SWNT) in a polymeric composite and contrast it to conventional fibers. The aspect ratio requ...

A new three-dimensional unit cell model has been developed for modeling three constituent phases including inclusion, interphase and matrix. The total elastic modulus of nano-composite is evaluated.  Numerical results are in good agreement with the previous proposed theoretical modeling. Higher matrix and inclusion elastic modulus both can dramatically influence the total elastic modulus.

In order to describe directly interphase properties of composite, force modulation of atomic force microscopy is adopted to study the cross-section of unidirectional carbon fiber/epoxy composites systematically. Research results indicate that in force modulation mode of AFM, relative stiffness of various phases distinct in distribution, which is described by probability histogram of relative st...