Interleukin-6 (IL-6) spielt eine wichtige Rolle bei der Pathogenese rheumatoiden Arthritis (RA). Mittlerweile sind gegen den IL-6-Signalweg gerichtete monoklonale Antikörper (z. B. Sarilumab) zur Therapie RA zugelassen. Lässt sich anhand des initialen IL-6-Serumspiegels das Therapieansprechen voraussagen? Dieser Frage ging ein Team internationaler Wissenschaftler mithilfe einer post hoc-Analyse...

Abstract Background Psoriatic arthritis (PsA) is a chronic multi-domains autoimmune inflammatory disorder. Patients with PsA have significant prevalence of cardiovascular affection. Upregulated Interleukin-34 (IL-34) has been seen in many disorders, and also atherosclerotic plaques. The aim this observational case–control study was to evaluate the serum levels il-34 patients correlate between i...

background:  new discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. we aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. based on the general faster progression rate of wrist osteoarthritis, we hypothes...

background: correlation between diabetes mellitus (dm) and oral lichen planus (olp) seems probable. since interleukin‑8 (il‑8) is an important inflammatory mediator involved in both conditions, this study aimed to measure and compare the serum level of il‑8 in dm, olp, and dm + olp patients in comparison with healthy individuals. materials and methods: this cross sectional study was conducted o...

background: pre-eclampsia (pe) is a pregnancy associated disorder characterized by hyper-tension and proteinuria. the first 2 stages of pe cause dysfunction in uteroplacental perfusion and oxidative stress while the third stage of pe is due to the release of inflammatory and angiogenic factors, which could lead to maternal endothelial damage and systemic inflammatory response. in this study, we...

cytokine production  in response to allergens may influence the development of atopy- predisposing immune responses, initializing the  early programming of  allergy and  asthma. vitamin d  intake  may be  protective  due  to  its  immunoregulatory properties,  that  may contribute  to  influence the expression of  the atopic phenotype  initiated in early life. the objective of our study was to ...

Aim . To study the levels of pro-inflammatory biomarkers in patients with obstructive and non-obstructive coronary artery disease (CAD), to identify possible differences for diagnosing degree obstruction. Material methods The observational included two groups patients: (main group, stenosis <50%; n=30) (comparison hemodynamically significant according results angiography; CAD. interleukin-1β...

Inflammatory process is at the heart of artificial (artificial) purulent-inflammatory diseases soft tissues (APDST), which may lead to development phlegmon and abscesses site invasion within a three-day period. The study cytokine status rats with APDST allows us evaluate dynamics inflammation markers assess peculiarities pathological course in model inflammation. experiment was carried out on 1...

Introduction It has been previously identified that levels of peripheral inflammatory proteins, such as cytokines, are altered in people with schizophrenia spectrum disorders (SSD). Objectives As there is considerable inconsistency the literature respect to how profiles differ between acute and chronic stages SSD, a systematic review network meta-analysis was performed. Methods Records from CIN...